Optimized heparin adsorption using macroporous zeolites: A comprehensive study
Heparin is a highly valuable active pharmaceutical ingredient, typically derived from porcine intestinal mucosa. Traditionally, various commercial resins have been used as adsorbents for heparin extraction; however, there has been growing interest in exploring more cost-effective adsorbents in recen...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024174294 |
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| author | Katelyn R. Reid Alireza Tabibi Parisa Adami Benson Karimi |
| author_facet | Katelyn R. Reid Alireza Tabibi Parisa Adami Benson Karimi |
| author_sort | Katelyn R. Reid |
| collection | DOAJ |
| description | Heparin is a highly valuable active pharmaceutical ingredient, typically derived from porcine intestinal mucosa. Traditionally, various commercial resins have been used as adsorbents for heparin extraction; however, there has been growing interest in exploring more cost-effective adsorbents in recent years to improve heparin recovery. Zeolites, a typical aluminosilicate known for their high surface area, porosity, and thermal stability, were selected for evaluation in this study. We investigated the performance of two different zeolites, CBV901 and CBV10A, in recovering heparin. Our findings indicate that the CBV901 zeolite exhibits excellent efficiency (44 %) along with capacity (23.3 mg.g-1) for adsorption when used with porcine intestinal mucosa. A mechanistic analysis using kinetic and thermodynamic models revealed that the surface conditions were favorable for heparin adsorption. Additionally, we examined the effects of various conditions including adsorption time, as well as sorbent reusability for recovery process refinement. |
| format | Article |
| id | doaj-art-5380712f6f824cb1a2680436ab4fe08b |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-5380712f6f824cb1a2680436ab4fe08b2025-01-17T04:51:09ZengElsevierHeliyon2405-84402025-01-01111e41398Optimized heparin adsorption using macroporous zeolites: A comprehensive studyKatelyn R. Reid0Alireza Tabibi1Parisa Adami2Benson Karimi3Department of Physical and Environmental Sciences, Texas A&M University Corpus Christi, Corpus Christi, TX, 78412, USADepartment of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, IranDepartment of Chemistry, College of Science, University of Tehran, Tehran, IranDepartment of Physical and Environmental Sciences, Texas A&M University Corpus Christi, Corpus Christi, TX, 78412, USA; Corresponding author.Heparin is a highly valuable active pharmaceutical ingredient, typically derived from porcine intestinal mucosa. Traditionally, various commercial resins have been used as adsorbents for heparin extraction; however, there has been growing interest in exploring more cost-effective adsorbents in recent years to improve heparin recovery. Zeolites, a typical aluminosilicate known for their high surface area, porosity, and thermal stability, were selected for evaluation in this study. We investigated the performance of two different zeolites, CBV901 and CBV10A, in recovering heparin. Our findings indicate that the CBV901 zeolite exhibits excellent efficiency (44 %) along with capacity (23.3 mg.g-1) for adsorption when used with porcine intestinal mucosa. A mechanistic analysis using kinetic and thermodynamic models revealed that the surface conditions were favorable for heparin adsorption. Additionally, we examined the effects of various conditions including adsorption time, as well as sorbent reusability for recovery process refinement.http://www.sciencedirect.com/science/article/pii/S2405844024174294ZeoliteHeparinPorous adsorbentsHeparin adsorptionY-zeolites adsorptionKinetic and thermodynamics |
| spellingShingle | Katelyn R. Reid Alireza Tabibi Parisa Adami Benson Karimi Optimized heparin adsorption using macroporous zeolites: A comprehensive study Heliyon Zeolite Heparin Porous adsorbents Heparin adsorption Y-zeolites adsorption Kinetic and thermodynamics |
| title | Optimized heparin adsorption using macroporous zeolites: A comprehensive study |
| title_full | Optimized heparin adsorption using macroporous zeolites: A comprehensive study |
| title_fullStr | Optimized heparin adsorption using macroporous zeolites: A comprehensive study |
| title_full_unstemmed | Optimized heparin adsorption using macroporous zeolites: A comprehensive study |
| title_short | Optimized heparin adsorption using macroporous zeolites: A comprehensive study |
| title_sort | optimized heparin adsorption using macroporous zeolites a comprehensive study |
| topic | Zeolite Heparin Porous adsorbents Heparin adsorption Y-zeolites adsorption Kinetic and thermodynamics |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024174294 |
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