Diagnostic value of Krebs von den Lungen-6, a serological biomarker in interstitial lung disease
Introduction: Krebs von den Lungen-6 (KL-6) biomarker has proven to be associated in the pathogenesis of interstitial lung disease (ILD). With this background, this study was done to find the diagnostic role of KL-6 in the ILD. This included establishing the role of KL-6 as a crucial diagnostic mark...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Current Research in Scientific Medicine |
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| Online Access: | https://journals.lww.com/10.4103/jcrsm.jcrsm_33_24 |
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| author | Cherukumalli Navya Praveen Radhakrishnan S. Yuvarajan Reenaa Mohan |
| author_facet | Cherukumalli Navya Praveen Radhakrishnan S. Yuvarajan Reenaa Mohan |
| author_sort | Cherukumalli Navya |
| collection | DOAJ |
| description | Introduction:
Krebs von den Lungen-6 (KL-6) biomarker has proven to be associated in the pathogenesis of interstitial lung disease (ILD). With this background, this study was done to find the diagnostic role of KL-6 in the ILD. This included establishing the role of KL-6 as a crucial diagnostic marker in early diagnosis, disease severity assessment, and its progression.
Materials and Methods:
After obtaining institutional ethical clearance, the present hospital-based cross-sectional study was done among patients with ILD (n = 56) above 18 years of age, attending the respiratory medicine department of a tertiary care teaching hospital in Puducherry. History, clinical examination, blood investigation for serology and biomarkers, lung function test, and biopsy were done. The study participants were assessed for KL-6, and analysis was done using SPSS (Version_24) software.
Results:
Among the 56 study participants, the subtypes of ILD include idiopathic pulmonary fibrosis (IPF) in connective tissue disorder (CTD)-ILD and others with a frequency of 23.18 and 15, respectively. The mean age of the study participants was 57.27 ± 12.95 years with 55.4% female predominance. The mean value of the KL-6 among the study participants was 485.18 ± 63.74 U/mL with a significantly higher mean in CTD-ILD (563.61 ± 21.88 U/mL) when compared to IPF (467.17 ± 27.46 U/mL) and other subtypes of ILD (426.67 ± 30.62 U/mL).
Conclusion:
Among the subgroups of ILD, KL-6 had a higher mean value in CTD-ILD when compared to IPF and other subgroups which were statistically significant. KL-6 can be considered the reliable indicator for the clinical diagnosis of ILD with a cutoff of ≥400 U/mL. |
| format | Article |
| id | doaj-art-537723d121a1487db6086e98a1f2db42 |
| institution | Kabale University |
| issn | 2542-6273 2455-3069 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Current Research in Scientific Medicine |
| spelling | doaj-art-537723d121a1487db6086e98a1f2db422025-01-10T14:01:41ZengWolters Kluwer Medknow PublicationsJournal of Current Research in Scientific Medicine2542-62732455-30692024-12-0110215516110.4103/jcrsm.jcrsm_33_24Diagnostic value of Krebs von den Lungen-6, a serological biomarker in interstitial lung diseaseCherukumalli NavyaPraveen RadhakrishnanS. YuvarajanReenaa MohanIntroduction: Krebs von den Lungen-6 (KL-6) biomarker has proven to be associated in the pathogenesis of interstitial lung disease (ILD). With this background, this study was done to find the diagnostic role of KL-6 in the ILD. This included establishing the role of KL-6 as a crucial diagnostic marker in early diagnosis, disease severity assessment, and its progression. Materials and Methods: After obtaining institutional ethical clearance, the present hospital-based cross-sectional study was done among patients with ILD (n = 56) above 18 years of age, attending the respiratory medicine department of a tertiary care teaching hospital in Puducherry. History, clinical examination, blood investigation for serology and biomarkers, lung function test, and biopsy were done. The study participants were assessed for KL-6, and analysis was done using SPSS (Version_24) software. Results: Among the 56 study participants, the subtypes of ILD include idiopathic pulmonary fibrosis (IPF) in connective tissue disorder (CTD)-ILD and others with a frequency of 23.18 and 15, respectively. The mean age of the study participants was 57.27 ± 12.95 years with 55.4% female predominance. The mean value of the KL-6 among the study participants was 485.18 ± 63.74 U/mL with a significantly higher mean in CTD-ILD (563.61 ± 21.88 U/mL) when compared to IPF (467.17 ± 27.46 U/mL) and other subtypes of ILD (426.67 ± 30.62 U/mL). Conclusion: Among the subgroups of ILD, KL-6 had a higher mean value in CTD-ILD when compared to IPF and other subgroups which were statistically significant. KL-6 can be considered the reliable indicator for the clinical diagnosis of ILD with a cutoff of ≥400 U/mL.https://journals.lww.com/10.4103/jcrsm.jcrsm_33_24biomarkerconnective tissue disorder-interstitial lung diseaseinterstitial lung diseasekrebs von den lungen-6 |
| spellingShingle | Cherukumalli Navya Praveen Radhakrishnan S. Yuvarajan Reenaa Mohan Diagnostic value of Krebs von den Lungen-6, a serological biomarker in interstitial lung disease Journal of Current Research in Scientific Medicine biomarker connective tissue disorder-interstitial lung disease interstitial lung disease krebs von den lungen-6 |
| title | Diagnostic value of Krebs von den Lungen-6, a serological biomarker in interstitial lung disease |
| title_full | Diagnostic value of Krebs von den Lungen-6, a serological biomarker in interstitial lung disease |
| title_fullStr | Diagnostic value of Krebs von den Lungen-6, a serological biomarker in interstitial lung disease |
| title_full_unstemmed | Diagnostic value of Krebs von den Lungen-6, a serological biomarker in interstitial lung disease |
| title_short | Diagnostic value of Krebs von den Lungen-6, a serological biomarker in interstitial lung disease |
| title_sort | diagnostic value of krebs von den lungen 6 a serological biomarker in interstitial lung disease |
| topic | biomarker connective tissue disorder-interstitial lung disease interstitial lung disease krebs von den lungen-6 |
| url | https://journals.lww.com/10.4103/jcrsm.jcrsm_33_24 |
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