NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early Parkinson’s disease-like phenotypes in mice

NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early Parkinson’s disease-like phenotypes in mice

Abstract Background The expansion of GGC repeats (typically exceeding 60 repeats) in the 5’ untranslated region (UTR) of the NOTCH2NLC gene (N2C) is linked to N2C-related repeat expansion disorders (NREDs), such as neuronal intranuclear inclusion disease (NIID), frontotemporal dementia (FTD), essent...

Full description

Saved in:
Bibliographic Details
Main Authors: Haitao Tu, Xin Yi Yeo, Zhi-Wei Zhang, Wei Zhou, Jayne Yi Tan, Li Chi, Sook-Yoong Chia, Zhihong Li, Aik Yong Sim, Brijesh Kumar Singh, Dongrui Ma, Zhidong Zhou, Isabelle Bonne, Shuo-Chien Ling, Adeline S.L. Ng, Sangyong Jung, Eng-King Tan, Li Zeng
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Neurodegeneration
Subjects:
NOTCH2NLC
GGC repeat expansion
Intermediate repeat
AGC interruption
Mitochondrial dysfunction
Hyperexcitability
Online Access:https://doi.org/10.1186/s13024-024-00780-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items