Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier

Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier

Abstract Specialized secretory cells, including keratinocytes in the last viable layers of mammalian epidermis, utilize lysosome-related organelles (LROs) to exocytose distinct cargoes vital for tissue function. Here, we demonstrate that the Flower isoform, hFWE4, a putative Ca2+ channel that permit...

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Main Authors: Justin C. Rudd, Jos P. H. Smits, Patrick T. Kuwong, Rachel E. Johnson, Louise M. N. Monga, Ivonne M. J. J. van Vlijmen-Willems, Greer L. Porter, Peter O. Halloran, Kanika Sharma, Karina N. Schmidt, Vikas Kumar, Justin G. Madson, Mrinal K. Sarkar, Ellen H. van den Bogaard, James A. Grunkemeyer, Johann E. Gudjonsson, Sunny Y. Wong, Cory L. Simpson, Laura A. Hansen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62105-1
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