Epidemiological and clinical features of patients with Clostridoides difficile infection
AIM: Investigation and identification of epidemiological characteristics, risk factors and treatment regimens effectivity in reducing morbidity and mortality. BACKGROUND: C.difficile remains the leading cause of health care associated diarrhea, usually as a result of irrational use of antimicrobial...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524003345 |
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| author | Arlinda Lloga Osmani Georgi Eftimovski Ivan Vidinic Kostadin Poposki Dajana Georgievska Zhaklina Shopova |
| author_facet | Arlinda Lloga Osmani Georgi Eftimovski Ivan Vidinic Kostadin Poposki Dajana Georgievska Zhaklina Shopova |
| author_sort | Arlinda Lloga Osmani |
| collection | DOAJ |
| description | AIM: Investigation and identification of epidemiological characteristics, risk factors and treatment regimens effectivity in reducing morbidity and mortality. BACKGROUND: C.difficile remains the leading cause of health care associated diarrhea, usually as a result of irrational use of antimicrobial therapy. METHODS: Retrospective descriptive study (October 2020-january2024) included all patients with clinical symptoms of Clostridoides difficile infection (CDI) admitted at our clinic. Diagnosis is based on isolation with coproculture for C.difficile, toxin confirmation with immunochromatography, small number confirmed with PCR film array. RESULTS: 594 inpatients with clinical symptoms of CDI were evaluated and diagnosis was confirmed in 44. Average mean age was 58,5 (29-90)years, approximately with no differencies on sex representation. Comorbidities and previous hospitalisations were noted in two third of them, and 63% had used antimicrobial drugs, while 34% had history of corticosteroid usage and 4,5% imunosupressive therapy. Often used antibiotics cephalosporins, clindamycine, quinolones and macrolides. 68,2% had history of protein pump inhibitors usage. Culture positive were 38%, toxinA/B is confirmed with immunochromatography in 77% of patients, PCR film array confirmed C.difficile toxin A/B in the remaining patients. Treatment is carried out with oral vancomycine in 56% of patients, 15% with metronidazole and the remaining with combination of two drugs. Regarding outcomes 90% of patients were cured while 10% had fatal outcomes and CDI is not considered the main cause of death. CONCLUSION: Elderly patients with antibiotic history treatment, previous healthcare exposures and comorbidities were the most affected by CDI infection. Metronidazole and vancomycine has shown good therapeutic results. |
| format | Article |
| id | doaj-art-530c0decc37544aa9d28e3ac3b18187f |
| institution | Kabale University |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-530c0decc37544aa9d28e3ac3b18187f2024-12-27T04:08:38ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-013949Epidemiological and clinical features of patients with Clostridoides difficile infectionArlinda Lloga Osmani0Georgi Eftimovski1Ivan Vidinic2Kostadin Poposki3Dajana Georgievska4Zhaklina Shopova5Clinic for infectious disease Skopje, North MacedoniaClinic for infectious disease Skopje, North MacedoniaClinic for infectious disease Skopje, North MacedoniaClinic for infectious disease Skopje, North MacedoniaClinic for infectious disease Skopje, North MacedoniaClinic for infectious disease Skopje, North MacedoniaAIM: Investigation and identification of epidemiological characteristics, risk factors and treatment regimens effectivity in reducing morbidity and mortality. BACKGROUND: C.difficile remains the leading cause of health care associated diarrhea, usually as a result of irrational use of antimicrobial therapy. METHODS: Retrospective descriptive study (October 2020-january2024) included all patients with clinical symptoms of Clostridoides difficile infection (CDI) admitted at our clinic. Diagnosis is based on isolation with coproculture for C.difficile, toxin confirmation with immunochromatography, small number confirmed with PCR film array. RESULTS: 594 inpatients with clinical symptoms of CDI were evaluated and diagnosis was confirmed in 44. Average mean age was 58,5 (29-90)years, approximately with no differencies on sex representation. Comorbidities and previous hospitalisations were noted in two third of them, and 63% had used antimicrobial drugs, while 34% had history of corticosteroid usage and 4,5% imunosupressive therapy. Often used antibiotics cephalosporins, clindamycine, quinolones and macrolides. 68,2% had history of protein pump inhibitors usage. Culture positive were 38%, toxinA/B is confirmed with immunochromatography in 77% of patients, PCR film array confirmed C.difficile toxin A/B in the remaining patients. Treatment is carried out with oral vancomycine in 56% of patients, 15% with metronidazole and the remaining with combination of two drugs. Regarding outcomes 90% of patients were cured while 10% had fatal outcomes and CDI is not considered the main cause of death. CONCLUSION: Elderly patients with antibiotic history treatment, previous healthcare exposures and comorbidities were the most affected by CDI infection. Metronidazole and vancomycine has shown good therapeutic results.http://www.sciencedirect.com/science/article/pii/S2213716524003345clostridoides difficilerisk factorsantimicrobial therapy |
| spellingShingle | Arlinda Lloga Osmani Georgi Eftimovski Ivan Vidinic Kostadin Poposki Dajana Georgievska Zhaklina Shopova Epidemiological and clinical features of patients with Clostridoides difficile infection Journal of Global Antimicrobial Resistance clostridoides difficile risk factors antimicrobial therapy |
| title | Epidemiological and clinical features of patients with Clostridoides difficile infection |
| title_full | Epidemiological and clinical features of patients with Clostridoides difficile infection |
| title_fullStr | Epidemiological and clinical features of patients with Clostridoides difficile infection |
| title_full_unstemmed | Epidemiological and clinical features of patients with Clostridoides difficile infection |
| title_short | Epidemiological and clinical features of patients with Clostridoides difficile infection |
| title_sort | epidemiological and clinical features of patients with clostridoides difficile infection |
| topic | clostridoides difficile risk factors antimicrobial therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524003345 |
| work_keys_str_mv | AT arlindallogaosmani epidemiologicalandclinicalfeaturesofpatientswithclostridoidesdifficileinfection AT georgieftimovski epidemiologicalandclinicalfeaturesofpatientswithclostridoidesdifficileinfection AT ivanvidinic epidemiologicalandclinicalfeaturesofpatientswithclostridoidesdifficileinfection AT kostadinpoposki epidemiologicalandclinicalfeaturesofpatientswithclostridoidesdifficileinfection AT dajanageorgievska epidemiologicalandclinicalfeaturesofpatientswithclostridoidesdifficileinfection AT zhaklinashopova epidemiologicalandclinicalfeaturesofpatientswithclostridoidesdifficileinfection |