Umbilical cord mesenchymal stem cells: A novel approach to intervention of ovarian ageing
Ovarian aging leads to endocrine disorders and systemic degeneration of tissue and organ structure and function, seriously affecting women's physical and mental health. Safe and effective treatments for this condition are lacking. Umbilical cord mesenchymal stem cells (UCMSCs), which have multi...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320424001421 |
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| author | Chuan Tian Li Ye Xilong Zhao Xiangqing Zhu Jun Xu Xinghua Pan |
| author_facet | Chuan Tian Li Ye Xilong Zhao Xiangqing Zhu Jun Xu Xinghua Pan |
| author_sort | Chuan Tian |
| collection | DOAJ |
| description | Ovarian aging leads to endocrine disorders and systemic degeneration of tissue and organ structure and function, seriously affecting women's physical and mental health. Safe and effective treatments for this condition are lacking. Umbilical cord mesenchymal stem cells (UCMSCs), which have multidirectional differentiation potential, show strong self-renewal, secrete bioactive factors and release exosomes, can undergo homing, colonization, integration and differentiation into supporting and functional cells in tissues and organs through direct manipulation and can also improve the tissue microenvironment through paracrine action, promoting cell division, proliferation and microangiogenesis, inhibiting inflammation and apoptosis, reducing oxidative stress, and mediating two-way immune regulation. These processes activate dormant cells, repaired damaged cells, replace necrotic cells, and regenerate fresh cells, restoring the structure and function of the ageing ovary. Furthermore, with the increasing development of UCMSC research and technology, the therapeutic use of UCMSCs is expected to become an effective means for the treatment of ovarian ageing caused by tissue cell ageing, degeneration, and necrosis. |
| format | Article |
| id | doaj-art-52fde6c1b16f4bb1b12ec8a7c589d12d |
| institution | Kabale University |
| issn | 2352-3204 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-52fde6c1b16f4bb1b12ec8a7c589d12d2024-11-30T07:10:55ZengElsevierRegenerative Therapy2352-32042024-06-0126590598Umbilical cord mesenchymal stem cells: A novel approach to intervention of ovarian ageingChuan Tian0Li Ye1Xilong Zhao2Xiangqing Zhu3Jun Xu4Xinghua Pan5The Basic Medical Laboratory of the 920th Hospital of Joint Logistics Support Force of PLA, The Transfer Medicine Key Laboratory of Cell Therapy Technology of Yunan Province, The Integrated Engineering Laboratory of Cell Biological Medicine of State and Regions, Kunming 650032, Yunnan Province, China; East Hospital, Stem Cell Research Center, School of Medicine, Tongji University, Shanghai 200331, ChinaThe Basic Medical Laboratory of the 920th Hospital of Joint Logistics Support Force of PLA, The Transfer Medicine Key Laboratory of Cell Therapy Technology of Yunan Province, The Integrated Engineering Laboratory of Cell Biological Medicine of State and Regions, Kunming 650032, Yunnan Province, ChinaThe Basic Medical Laboratory of the 920th Hospital of Joint Logistics Support Force of PLA, The Transfer Medicine Key Laboratory of Cell Therapy Technology of Yunan Province, The Integrated Engineering Laboratory of Cell Biological Medicine of State and Regions, Kunming 650032, Yunnan Province, ChinaThe Basic Medical Laboratory of the 920th Hospital of Joint Logistics Support Force of PLA, The Transfer Medicine Key Laboratory of Cell Therapy Technology of Yunan Province, The Integrated Engineering Laboratory of Cell Biological Medicine of State and Regions, Kunming 650032, Yunnan Province, ChinaEast Hospital, Stem Cell Research Center, School of Medicine, Tongji University, Shanghai 200331, China; Corresponding author.The Basic Medical Laboratory of the 920th Hospital of Joint Logistics Support Force of PLA, The Transfer Medicine Key Laboratory of Cell Therapy Technology of Yunan Province, The Integrated Engineering Laboratory of Cell Biological Medicine of State and Regions, Kunming 650032, Yunnan Province, China; Corresponding author.Ovarian aging leads to endocrine disorders and systemic degeneration of tissue and organ structure and function, seriously affecting women's physical and mental health. Safe and effective treatments for this condition are lacking. Umbilical cord mesenchymal stem cells (UCMSCs), which have multidirectional differentiation potential, show strong self-renewal, secrete bioactive factors and release exosomes, can undergo homing, colonization, integration and differentiation into supporting and functional cells in tissues and organs through direct manipulation and can also improve the tissue microenvironment through paracrine action, promoting cell division, proliferation and microangiogenesis, inhibiting inflammation and apoptosis, reducing oxidative stress, and mediating two-way immune regulation. These processes activate dormant cells, repaired damaged cells, replace necrotic cells, and regenerate fresh cells, restoring the structure and function of the ageing ovary. Furthermore, with the increasing development of UCMSC research and technology, the therapeutic use of UCMSCs is expected to become an effective means for the treatment of ovarian ageing caused by tissue cell ageing, degeneration, and necrosis.http://www.sciencedirect.com/science/article/pii/S2352320424001421Umbilical cord mesenchymal stem cellsOvarian ageingAgeingDegeneration |
| spellingShingle | Chuan Tian Li Ye Xilong Zhao Xiangqing Zhu Jun Xu Xinghua Pan Umbilical cord mesenchymal stem cells: A novel approach to intervention of ovarian ageing Regenerative Therapy Umbilical cord mesenchymal stem cells Ovarian ageing Ageing Degeneration |
| title | Umbilical cord mesenchymal stem cells: A novel approach to intervention of ovarian ageing |
| title_full | Umbilical cord mesenchymal stem cells: A novel approach to intervention of ovarian ageing |
| title_fullStr | Umbilical cord mesenchymal stem cells: A novel approach to intervention of ovarian ageing |
| title_full_unstemmed | Umbilical cord mesenchymal stem cells: A novel approach to intervention of ovarian ageing |
| title_short | Umbilical cord mesenchymal stem cells: A novel approach to intervention of ovarian ageing |
| title_sort | umbilical cord mesenchymal stem cells a novel approach to intervention of ovarian ageing |
| topic | Umbilical cord mesenchymal stem cells Ovarian ageing Ageing Degeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2352320424001421 |
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