Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating OccurrenceSummary
The onset of colorectal cancer (CRC) in patients younger than 50 continues to rapidly increase. This study highlights the epidemiologic changes, risk factors, clinical characteristics, and molecular profiles prevalent in early onset CRC patients, and identifies key areas for future research. It has...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X24001802 |
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| _version_ | 1841526269788815360 |
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| author | Atehkeng Zinkeng F. Lloyd Taylor Samuel H. Cheong Heyu Song Juanita L. Merchant |
| author_facet | Atehkeng Zinkeng F. Lloyd Taylor Samuel H. Cheong Heyu Song Juanita L. Merchant |
| author_sort | Atehkeng Zinkeng |
| collection | DOAJ |
| description | The onset of colorectal cancer (CRC) in patients younger than 50 continues to rapidly increase. This study highlights the epidemiologic changes, risk factors, clinical characteristics, and molecular profiles prevalent in early onset CRC patients, and identifies key areas for future research. It has been noted that only a small fraction of early onset CRC cases is attributed to known hereditary mutations and fit the canonical pathway of late-onset colorectal cancer development. To highlight this, we review the genetic and epigenetic modifications specific to early onset CRC. We also discuss the synergetic effect of single-nucleotide polymorphisms and environmental factors on the early onset of CRC. Additionally, we discuss the potential of noninvasive biomarker assays to enhance early detection, screening, diagnosis, and prognostic outcome predictions. |
| format | Article |
| id | doaj-art-52e371d0ae594ac5a87f6797f0cde580 |
| institution | Kabale University |
| issn | 2352-345X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj-art-52e371d0ae594ac5a87f6797f0cde5802025-01-17T04:49:36ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2025-01-01192101425Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating OccurrenceSummaryAtehkeng Zinkeng0F. Lloyd Taylor1Samuel H. Cheong2Heyu Song3Juanita L. Merchant4Medical Scientist Training Program, University of Arizona College of Medicine, Tucson, ArizonaUniversidad Autonoma de GuadalajaraUniversity of Arizona College of Medicine, Tucson, ArizonaUniversity of ArizonaDepartment of Medicine, University of Arizona College of Medicine, Tucson, Arizona; Correspondence Address correspondence to: Juanita L. Merchant, MD, PhD, Department of Medicine, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, Arizona 85724.The onset of colorectal cancer (CRC) in patients younger than 50 continues to rapidly increase. This study highlights the epidemiologic changes, risk factors, clinical characteristics, and molecular profiles prevalent in early onset CRC patients, and identifies key areas for future research. It has been noted that only a small fraction of early onset CRC cases is attributed to known hereditary mutations and fit the canonical pathway of late-onset colorectal cancer development. To highlight this, we review the genetic and epigenetic modifications specific to early onset CRC. We also discuss the synergetic effect of single-nucleotide polymorphisms and environmental factors on the early onset of CRC. Additionally, we discuss the potential of noninvasive biomarker assays to enhance early detection, screening, diagnosis, and prognostic outcome predictions.http://www.sciencedirect.com/science/article/pii/S2352345X24001802Mature Onset Diabetes of the YoungNonhereditaryDNA MutationSingle Nucleotide PolymorphismsEpigeneticsTumor Microenvironment |
| spellingShingle | Atehkeng Zinkeng F. Lloyd Taylor Samuel H. Cheong Heyu Song Juanita L. Merchant Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating OccurrenceSummary Cellular and Molecular Gastroenterology and Hepatology Mature Onset Diabetes of the Young Nonhereditary DNA Mutation Single Nucleotide Polymorphisms Epigenetics Tumor Microenvironment |
| title | Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating OccurrenceSummary |
| title_full | Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating OccurrenceSummary |
| title_fullStr | Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating OccurrenceSummary |
| title_full_unstemmed | Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating OccurrenceSummary |
| title_short | Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating OccurrenceSummary |
| title_sort | early onset colorectal cancer molecular underpinnings accelerating occurrencesummary |
| topic | Mature Onset Diabetes of the Young Nonhereditary DNA Mutation Single Nucleotide Polymorphisms Epigenetics Tumor Microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X24001802 |
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