Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners
Canine osteoarthritis (OA) stands as a prevalent and excruciating joint condition that represents a promising application of stromal vascular fraction (SVF) treatment. In this review, we discuss the multi-factorial advantage of SVF cited as anti-inflammatory, regenerative, and angiogenic, all of whi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2025.1586629/full |
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| author | Aline Yen Ling Wang Ana Elena Aviña Ana Elena Aviña Yen-Yu Liu Huang-Kai Kao Huang-Kai Kao |
| author_facet | Aline Yen Ling Wang Ana Elena Aviña Ana Elena Aviña Yen-Yu Liu Huang-Kai Kao Huang-Kai Kao |
| author_sort | Aline Yen Ling Wang |
| collection | DOAJ |
| description | Canine osteoarthritis (OA) stands as a prevalent and excruciating joint condition that represents a promising application of stromal vascular fraction (SVF) treatment. In this review, we discuss the multi-factorial advantage of SVF cited as anti-inflammatory, regenerative, and angiogenic, all of which improve the complex pathology of OA. The heterogeneous cellular structure of SVF allows it to achieve joint improvement through both cell-based tissue restoration and signaling functions that benefit joint health. Veterinary practitioners need to consider essential aspects for clinical practice including patient selection criteria together with specific dosage recommendations along with additional therapies like platelet-rich plasma. Existing clinical data shows that SVF reduces pain while helping restore joint functions while practitioners face challenges when standardizing protocols and evaluating long-term safety aspects. Future research initiatives aim to translate advanced technologies including bioactive scaffolds, gene editing, and artificial intelligence which show promise for enhancing therapeutic results. This review integrates existing information about SVF while enlightening veterinarians about the gap areas to assist them make informed decisions when implementing SVF in practice. SVF represents a huge step forward in veterinary regenerative medicine because it enables better management of OA as well as other orthopedic applications. |
| format | Article |
| id | doaj-art-52d2c2c61a3541c69bd4635ec6f77d0b |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-52d2c2c61a3541c69bd4635ec6f77d0b2025-08-20T03:49:46ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-05-011210.3389/fvets.2025.15866291586629Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitionersAline Yen Ling Wang0Ana Elena Aviña1Ana Elena Aviña2Yen-Yu Liu3Huang-Kai Kao4Huang-Kai Kao5Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, TaiwanCenter for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, TaiwanInternational PhD Program in Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanCenter for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanCanine osteoarthritis (OA) stands as a prevalent and excruciating joint condition that represents a promising application of stromal vascular fraction (SVF) treatment. In this review, we discuss the multi-factorial advantage of SVF cited as anti-inflammatory, regenerative, and angiogenic, all of which improve the complex pathology of OA. The heterogeneous cellular structure of SVF allows it to achieve joint improvement through both cell-based tissue restoration and signaling functions that benefit joint health. Veterinary practitioners need to consider essential aspects for clinical practice including patient selection criteria together with specific dosage recommendations along with additional therapies like platelet-rich plasma. Existing clinical data shows that SVF reduces pain while helping restore joint functions while practitioners face challenges when standardizing protocols and evaluating long-term safety aspects. Future research initiatives aim to translate advanced technologies including bioactive scaffolds, gene editing, and artificial intelligence which show promise for enhancing therapeutic results. This review integrates existing information about SVF while enlightening veterinarians about the gap areas to assist them make informed decisions when implementing SVF in practice. SVF represents a huge step forward in veterinary regenerative medicine because it enables better management of OA as well as other orthopedic applications.https://www.frontiersin.org/articles/10.3389/fvets.2025.1586629/fullstromal vascular fractionSVFcanine osteoarthritisregenerative medicineveterinary orthopedicsinflammation modulation |
| spellingShingle | Aline Yen Ling Wang Ana Elena Aviña Ana Elena Aviña Yen-Yu Liu Huang-Kai Kao Huang-Kai Kao Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners Frontiers in Veterinary Science stromal vascular fraction SVF canine osteoarthritis regenerative medicine veterinary orthopedics inflammation modulation |
| title | Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners |
| title_full | Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners |
| title_fullStr | Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners |
| title_full_unstemmed | Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners |
| title_short | Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners |
| title_sort | stromal vascular fraction in canine osteoarthritis advantages applications and insights for veterinary practitioners |
| topic | stromal vascular fraction SVF canine osteoarthritis regenerative medicine veterinary orthopedics inflammation modulation |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2025.1586629/full |
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