KDM6A facilitates Xist upregulation at the onset of X inactivation

KDM6A facilitates Xist upregulation at the onset of X inactivation

Abstract Background X chromosome inactivation (XCI) is a female-specific process in which one X chromosome is silenced to balance X-linked gene expression between the sexes. XCI is initiated in early development by upregulation of the lncRNA Xist on the future inactive X (Xi). A subset of X-linked g...

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Main Authors: Josephine Lin, Jinli Zhang, Li Ma, He Fang, Rui Ma, Camille Groneck, Galina N. Filippova, Xinxian Deng, Chizuru Kinoshita, Jessica E. Young, Wenxiu Ma, Christine M. Disteche, Joel B. Berletch
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Biology of Sex Differences
Subjects:
Allele-specific
Epigenetics
X inactivation
Histone methylation
Dosage compensation
Escape
Online Access:https://doi.org/10.1186/s13293-024-00683-3
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