Developing a multivariable prediction model for functional outcome after reperfusion therapy for acute ischaemic stroke: study protocol for the Targeting Optimal Thrombolysis Outcomes (TOTO) multicentre cohort study

Developing a multivariable prediction model for functional outcome after reperfusion therapy for acute ischaemic stroke: study protocol for the Targeting Optimal Thrombolysis Outcomes (TOTO) multicentre cohort study

Introduction Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) is the only approved pharmacological reperfusion therapy for acute ischaemic stroke. Despite population benefit, IVT is not equally effective in all patients, nor is it without significant risk. Uncerta...

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Main Authors: Elizabeth Holliday, Timothy Kleinig, Thomas Lillicrap, Philip M C Choi, Jane Maguire, Andrew Bivard, Lisa F Lincz, Monica Anne Hamilton-Bruce, Sushma R Rao, Marten F Snel, Paul J Trim, Longting Lin, Mark W Parsons, Bradford B Worrall, Simon Koblar, Chris Levi
Format: Article
Language:English
Published: BMJ Publishing Group 2020-04-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/10/4/e038180.full
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