Molecular Imaging of Hypoxia-Inducible Factor 1α and von Hippel-Lindau Interaction in Mice

Molecular Imaging of Hypoxia-Inducible Factor 1α and von Hippel-Lindau Interaction in Mice

Tumor hypoxia plays a crucial role in tumorigenesis. Under hypoxia, hypoxia-inducible factor 1α (HIF-1α) regulates activation of genes promoting malignant progression. Under normoxia, HIF-1α is hydroxylated on prolines 402 and 564 and is targeted for ubiquitin-mediated degradation by interacting wit...

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Main Authors: Clara Y.H. Choi, Denise A. Chan, Ramasamy Paulmurugan, Patrick D. Sutphin, Quynh-Thu Le, Albert C. Koong, Wayne Zundel, Sanjiv S. Gambhir, Amato J. Giaccia
Format: Article
Language:English
Published: SAGE Publishing 2008-05-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2008.00017
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