Rational protein engineering of thermostable heparinase Ⅰ from Bacteroides thetaiotaomicron for highly efficient heparin degradation

Heparin, a glycosaminoglycan, is a stable source of carbon that supports the growth of microorganisms in the human intestine. It is also a commonly used anticoagulant drug in clinical practice, with significant therapeutic effects. Low molecular weight heparin (LMWH) is a highly active low molecular...

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Bibliographic Details
Main Authors: Chuan Zhang, Ruohan Zhao, Leilei Yu, Qixiao Zhai, Jianxin Zhao, Hao Zhang, Xuegang Luo, Fengwei Tian, Wei Chen
Format: Article
Language:English
Published: Tsinghua University Press 2025-06-01
Series:Food Science and Human Wellness
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Online Access:https://www.sciopen.com/article/10.26599/FSHW.2024.9250134
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