Modulating cytokine microenvironment during T cell activation induces protective RSV-specific lung resident memory T cells in early life in mice
Abstract Maternal immunisation against respiratory viruses provides protection in early life, but as antibodies wane, there can be a gap in coverage. This immunity gap might be filled by inducing pathogen-specific lung tissue-resident T cells (TRM). However, the neonatal mouse lung has a different i...
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Main Authors: | Ziyin Wang, Miko Zhong, Chubicka Thomas, Ekaterina Kinnear, Tom Rice, Beth Holder, Beate Kampmann, John S. Tregoning |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-12-01
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Series: | npj Viruses |
Online Access: | https://doi.org/10.1038/s44298-024-00073-x |
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