Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China?
Objective Endometriosis is considered as a serious gynaecological disease in women at a reproductive age. Lower body mass index (BMI) is thought to be a risk factor. However, recent studies indicated that women with normal BMI were also more likely to develop endometriosis, suggesting the associatio...
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| Format: | Article |
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e037095.full |
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| author | Qi Chen Yifei Gao Yunhui Tang Luling Lin Mingzhi Zhao George Qiaoqi Chen Shouzhen Chen |
| author_facet | Qi Chen Yifei Gao Yunhui Tang Luling Lin Mingzhi Zhao George Qiaoqi Chen Shouzhen Chen |
| author_sort | Qi Chen |
| collection | DOAJ |
| description | Objective Endometriosis is considered as a serious gynaecological disease in women at a reproductive age. Lower body mass index (BMI) is thought to be a risk factor. However, recent studies indicated that women with normal BMI were also more likely to develop endometriosis, suggesting the association with BMI is controversial. We therefore investigated the association of BMI and surgically diagnosed endometriosis in a cohort of Chinese women.Design Retrospective case–control study.Setting Tertiary hospital.Patients 709 women with endometriosis and 807 age matched controls between January 2018 and August 2019.Intervention Age at diagnosis, parity, gravida, BMI and self-reported dysmenorrhoea status were collected and the association of BMI and endometriosis was analysed.Measurement and main results Overall, the median BMI was not different between patients and controls (21.1 kg/m2 vs 20.9 kg/m2, p=0.223). According to the BMI categories for Asians/Chinese by WHO (underweight: <18.5 kg/m2, normal weight: 18.5–22.99 kg/m2, overweight: 23–27.49 kg/m2, obese: ≥27.50 kg/m2), overall, there was no difference in the association of BMI and endometriosis (p=0.112). 60% of patients were of normal weight. However, the OR of obese patients (BMI over 27.50 kg/m2) having endometriosis was1.979 (95% CI 1.15 to 3.52, p=0.0185), compared with women with normal weight. 50.3% patients reported dysmenorrhoea, and the OR of developing severe dysmenorrhoea in obese patients (BMI over 27.50 kg/m2) was 3.64 (95% CI 1.195 to 10.15, p=0.025), compared with patients with normal weight.Conclusion Our data demonstrate that overall there was no association between BMI and the incidence of endometriosis, but there was a significant increase in the incidence of endometriosis in obese women, compared with women with normal weight. Obesity was also a risk factor for severe dysmenorrhoea. |
| format | Article |
| id | doaj-art-52641e8cae4a44268b667530c40654b6 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-52641e8cae4a44268b667530c40654b62025-01-08T07:20:11ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2020-037095Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China?Qi Chen0Yifei Gao1Yunhui Tang2Luling Lin3Mingzhi Zhao4George Qiaoqi Chen5Shouzhen Chen6Silberman School of Social Work, Hunter College City University of New York, New York, New York, USA4 The Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai, China1 Department of Family Planning, The Hospital of Obstetrics and Gynaecology, Fudan University, Shanghai, ChinaLiggins Institute, The University of Auckland, Auckland, New ZealandDepartment of Rehabilitation, Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital, Beijing, China5 School of Medicine, The University of Manchester, Manchester, UK2 Department of Gynaecology, The Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai, ChinaObjective Endometriosis is considered as a serious gynaecological disease in women at a reproductive age. Lower body mass index (BMI) is thought to be a risk factor. However, recent studies indicated that women with normal BMI were also more likely to develop endometriosis, suggesting the association with BMI is controversial. We therefore investigated the association of BMI and surgically diagnosed endometriosis in a cohort of Chinese women.Design Retrospective case–control study.Setting Tertiary hospital.Patients 709 women with endometriosis and 807 age matched controls between January 2018 and August 2019.Intervention Age at diagnosis, parity, gravida, BMI and self-reported dysmenorrhoea status were collected and the association of BMI and endometriosis was analysed.Measurement and main results Overall, the median BMI was not different between patients and controls (21.1 kg/m2 vs 20.9 kg/m2, p=0.223). According to the BMI categories for Asians/Chinese by WHO (underweight: <18.5 kg/m2, normal weight: 18.5–22.99 kg/m2, overweight: 23–27.49 kg/m2, obese: ≥27.50 kg/m2), overall, there was no difference in the association of BMI and endometriosis (p=0.112). 60% of patients were of normal weight. However, the OR of obese patients (BMI over 27.50 kg/m2) having endometriosis was1.979 (95% CI 1.15 to 3.52, p=0.0185), compared with women with normal weight. 50.3% patients reported dysmenorrhoea, and the OR of developing severe dysmenorrhoea in obese patients (BMI over 27.50 kg/m2) was 3.64 (95% CI 1.195 to 10.15, p=0.025), compared with patients with normal weight.Conclusion Our data demonstrate that overall there was no association between BMI and the incidence of endometriosis, but there was a significant increase in the incidence of endometriosis in obese women, compared with women with normal weight. Obesity was also a risk factor for severe dysmenorrhoea.https://bmjopen.bmj.com/content/10/9/e037095.full |
| spellingShingle | Qi Chen Yifei Gao Yunhui Tang Luling Lin Mingzhi Zhao George Qiaoqi Chen Shouzhen Chen Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China? BMJ Open |
| title | Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China? |
| title_full | Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China? |
| title_fullStr | Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China? |
| title_full_unstemmed | Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China? |
| title_short | Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China? |
| title_sort | is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea a case control study in china |
| url | https://bmjopen.bmj.com/content/10/9/e037095.full |
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