Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol
Introduction and aims Digital biomarkers can provide a cost-effective, objective and robust measure for neurological disease progression, changes in care needs and the effect of interventions. Motor function, physiology and behaviour can provide informative measures of neurological conditions and ne...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/8/e072094.full |
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| author | David J Sharp Rimona Weil James Bashford Adam Hampshire Lucia M Li Eyal Soreq Helen Lai Shlomi Haar Charalambos Hadjipanayi Adrien Rapeaux Damion Lambert Mark Crook-Rumsey Sarah J C Daniels Subati Abulikemu Julian Jeyasingh-Jacob Dragos C Gruia |
| author_facet | David J Sharp Rimona Weil James Bashford Adam Hampshire Lucia M Li Eyal Soreq Helen Lai Shlomi Haar Charalambos Hadjipanayi Adrien Rapeaux Damion Lambert Mark Crook-Rumsey Sarah J C Daniels Subati Abulikemu Julian Jeyasingh-Jacob Dragos C Gruia |
| author_sort | David J Sharp |
| collection | DOAJ |
| description | Introduction and aims Digital biomarkers can provide a cost-effective, objective and robust measure for neurological disease progression, changes in care needs and the effect of interventions. Motor function, physiology and behaviour can provide informative measures of neurological conditions and neurodegenerative decline. New digital technologies present an opportunity to provide remote, high-frequency monitoring of patients from within their homes. The purpose of the living lab study is to develop novel digital biomarkers of functional impairment in those living with neurodegenerative disease (NDD) and neurological conditions.Methods and analysis The Living Lab study is a cross-sectional observational study of cognition and behaviour in people living with NDDs and other, non-degenerative neurological conditions. Patients (n≥25 for each patient group) with dementia, Parkinson’s disease, amyotrophic lateral sclerosis, mild cognitive impairment, traumatic brain injury and stroke along with controls (n≥60) will be pragmatically recruited. Patients will carry out activities of daily living and functional assessments within the Living Lab. The Living Lab is an apartment-laboratory containing a functional kitchen, bathroom, bed and living area to provide a controlled environment to develop novel digital biomarkers. The Living Lab provides an important intermediary stage between the conventional laboratory and the home. Multiple passive environmental sensors, internet-enabled medical devices, wearables and electroencephalography (EEG) will be used to characterise functional impairments of NDDs and non-NDD conditions. We will also relate these digital technology measures to clinical and cognitive outcomes.Ethics and dissemination Ethical approvals have been granted by the Imperial College Research Ethics Committee (reference number: 21IC6992). Results from the study will be disseminated at conferences and within peer-reviewed journals. |
| format | Article |
| id | doaj-art-52460c4a1b64463c914bab49449dae0e |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-52460c4a1b64463c914bab49449dae0e2024-11-14T20:30:09ZengBMJ Publishing GroupBMJ Open2044-60552023-08-0113810.1136/bmjopen-2023-072094Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocolDavid J Sharp0Rimona Weil1James Bashford2Adam Hampshire3Lucia M Li4Eyal Soreq5Helen Lai6Shlomi Haar7Charalambos Hadjipanayi8Adrien Rapeaux9Damion Lambert10Mark Crook-Rumsey11Sarah J C Daniels12Subati Abulikemu13Julian Jeyasingh-Jacob14Dragos C Gruia15Care Research & Technology, UK Dementia Research Institute, London, UKNational Hospital for Neurology and Neurosurgery, UCLH, London, UKUK Dementia Research Institute, Basic and Clinical Neuroscience, King`s College London, London, UK8 Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UKDepartment of Brain Sciences, Imperial College London, London, UKUK Dementia Research Institute Care Research and Technology Centre, Imperial College London and the University of Surrey, London, UKUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UKUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UKUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UKUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UKUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UKUK Dementia Research Institute, Basic and Clinical Neuroscience, King`s College London, London, UKUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UKUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UKDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UKUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UKIntroduction and aims Digital biomarkers can provide a cost-effective, objective and robust measure for neurological disease progression, changes in care needs and the effect of interventions. Motor function, physiology and behaviour can provide informative measures of neurological conditions and neurodegenerative decline. New digital technologies present an opportunity to provide remote, high-frequency monitoring of patients from within their homes. The purpose of the living lab study is to develop novel digital biomarkers of functional impairment in those living with neurodegenerative disease (NDD) and neurological conditions.Methods and analysis The Living Lab study is a cross-sectional observational study of cognition and behaviour in people living with NDDs and other, non-degenerative neurological conditions. Patients (n≥25 for each patient group) with dementia, Parkinson’s disease, amyotrophic lateral sclerosis, mild cognitive impairment, traumatic brain injury and stroke along with controls (n≥60) will be pragmatically recruited. Patients will carry out activities of daily living and functional assessments within the Living Lab. The Living Lab is an apartment-laboratory containing a functional kitchen, bathroom, bed and living area to provide a controlled environment to develop novel digital biomarkers. The Living Lab provides an important intermediary stage between the conventional laboratory and the home. Multiple passive environmental sensors, internet-enabled medical devices, wearables and electroencephalography (EEG) will be used to characterise functional impairments of NDDs and non-NDD conditions. We will also relate these digital technology measures to clinical and cognitive outcomes.Ethics and dissemination Ethical approvals have been granted by the Imperial College Research Ethics Committee (reference number: 21IC6992). Results from the study will be disseminated at conferences and within peer-reviewed journals.https://bmjopen.bmj.com/content/13/8/e072094.full |
| spellingShingle | David J Sharp Rimona Weil James Bashford Adam Hampshire Lucia M Li Eyal Soreq Helen Lai Shlomi Haar Charalambos Hadjipanayi Adrien Rapeaux Damion Lambert Mark Crook-Rumsey Sarah J C Daniels Subati Abulikemu Julian Jeyasingh-Jacob Dragos C Gruia Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol BMJ Open |
| title | Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol |
| title_full | Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol |
| title_fullStr | Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol |
| title_full_unstemmed | Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol |
| title_short | Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol |
| title_sort | multicohort cross sectional study of cognitive and behavioural digital biomarkers in neurodegeneration the living lab study protocol |
| url | https://bmjopen.bmj.com/content/13/8/e072094.full |
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