Bergapten alleviates senescence of chondrocytes in osteoarthritis

Bergapten alleviates senescence of chondrocytes in osteoarthritis

Objective‍　‍To investigate the role and mechanism of bergapten in treating osteoarthritis (OA) based on network pharmacology, molecular docking and in vitro experiments. Methods‍　‍The functional targets of bergapten and the related targets of OA disease were obtained by searching Super-Pred， Swiss T...

Full description

Saved in:

Bibliographic Details
Main Authors:	YE Yuanlan, LIU Kaiwen, PAN Yiming
Format:	Article
Language:	zho
Published:	Editorial Office of Journal of Army Medical University 2025-02-01
Series:	陆军军医大学学报
Subjects:	‍osteoarthritis 5-methoxypsoralen network pharmacology senescence-associated secretory phenotype
Online Access:	https://aammt.tmmu.edu.cn/html/202408075.html
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Plants and fungi metabolites as novel autophagy inducers and senescence inhibitors
by: Rivka Ofir
Published: (2024-07-01)

Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects
by: Li H, et al.
Published: (2025-01-01)

Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis
by: Leonie Ruths, et al.
Published: (2025-01-01)

Construction and validation of a senescence-related gene signature for early prediction and treatment of osteoarthritis based on bioinformatics analysis
by: Yonggang Wang, et al.
Published: (2024-12-01)

Inhibition of miMOMP-induced SASP to combat age-related disease
by: Xiaoli Liao, et al.
Published: (2025-01-01)

Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways
by: Liang Zhu, et al.
Published: (2025-02-01)

The Interplay of Aging and PANoptosis in Osteoarthritis Pathogenesis: Implications for Novel Therapeutic Strategies
by: Liu S, et al.
Published: (2025-02-01)

Clinical phenotypes and associated factors in knee osteoarthritis in an African black population
by: Charles Sougué, et al.
Published: (2025-03-01)

Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence
by: Keyu Kong, et al.
Published: (2025-01-01)

Ginkgetin Alleviates Inflammation and Senescence by Targeting STING
by: Yadan Liu, et al.
Published: (2025-01-01)

Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis
by: Da-Long Dong, et al.
Published: (2025-01-01)

AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice
by: Zhuan Zou, et al.
Published: (2025-01-01)

Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders
by: Tábatha de Oliveira Silva, et al.
Published: (2025-01-01)

Effect of Electroacupuncture on Chondrocyte Apoptosis and Cartilage Matrix of Experimental Rats with Knee Osteoarthritis
by: Guangwen WU, et al.
Published: (2017-10-01)

Single-cell RNA sequencing identifies the expression of hemoglobin in chondrocyte cell subpopulations in osteoarthritis
by: Zhihao Zhang, et al.
Published: (2024-12-01)

Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis
by: Zheng D, et al.
Published: (2025-01-01)

The Hippo Signaling Pathway Manipulates Cellular Senescence
by: Chiharu Miyajima, et al.
Published: (2024-12-01)

Impacts of Tougu Xiaotong Capsule on Chondrocytes Ultrastructure and Cartilage Matrix in Rats with Early Stage Osteoarthritis
by: Xiaodong LU, et al.
Published: (2017-04-01)

High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis
by: Soon Sang Park, et al.
Published: (2025-02-01)

Alleviating the IL-1β-stimulated extracellular matrix degradation in osteoarthritis, and chondrocyte inflammation by Morinda officinalis polysaccharide via the SIRT6/NF-κB pathway
by: Dongfang Zhao, et al.
Published: (2025-01-01)

Exploring the impacts of senescence on implantation and early embryonic development using totipotent cell-derived blastoids
by: Yuxin Luo, et al.
Published: (2025-02-01)

Circadian clock regulation in soybean senescence: a transcriptome analysis of early and late senescence types
by: Prakash Basnet, et al.
Published: (2025-01-01)

Curcumin nanoparticles alleviate brain mitochondrial dysfunction and cellular senescence in γ-irradiated rats
by: Omnia A. Moselhy, et al.
Published: (2025-01-01)

The causal impact of smoking behavior on osteoarthritis: a Mendelian randomization analysis
by: Qiang Xiao, et al.
Published: (2025-01-01)

Skatole Alleviates Osteoarthritis by Reprogramming Macrophage Polarization and Protecting Chondrocytes
by: Weiyun Wang, et al.
Published: (2025-01-01)

Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma
by: Pengfei Zan, et al.
Published: (2025-01-01)

SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burden
by: Bethany K. Hughes, et al.
Published: (2025-01-01)

Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer’s Disease, Inflammation, and Senescence
by: Patrycja Kozubek, et al.
Published: (2024-12-01)

Identification and mechanistic insights of cell senescence-related genes in psoriasis
by: Guiyan Deng, et al.
Published: (2025-01-01)

Chloroplast Vesiculation and Induced Chloroplast Vesiculation and Senescence‐Associated Gene 12 Expression During Tomato Flower Pedicel Abscission
by: Magda Tušek Žnidarič, et al.
Published: (2025-01-01)

Wheat NAC transcription factor NAC5‐1 is a positive regulator of senescence
by: Catherine Evans, et al.
Published: (2024-07-01)

T cell immune senescence is associated with frailty and sarcopenia in lung transplant candidates
by: Joanna M. Schaenman, MD, PhD, et al.
Published: (2025-02-01)

Biocompatible ionized air alleviates rat osteoarthritis by modulating polarization from M1 to M2 macrophages
by: Haoran Yu, et al.
Published: (2024-12-01)

Study on the protective effect of naringin-regulated lncRNA GAS5 against mitochondrial apoptosis in osteoarthritic chondrocytes
by: LIN Qin, et al.
Published: (2025-01-01)

Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence
by: Nicola Alessio, et al.
Published: (2020-03-01)

Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue
by: Ashraf I. Khasawneh, et al.
Published: (2025-01-01)

Neuroprotective effects of gastrodin in both in vivo and in vitro models of Parkinson's disease: Mechanisms from the perspective of oxidative stress, ferroptosis, and cellular senescence
by: Shanshan Li, et al.
Published: (2025-02-01)

Identification and functional characterization of the MYB transcription factor GmMYBLJ in soybean leaf senescence
by: Guohua Bao, et al.
Published: (2025-01-01)

Protective effect of adiponectin on oxidative stress-induced ovarian granulosa cell senescence in geese
by: Yan Zheng, et al.
Published: (2025-01-01)

Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone?
by: Lara Russo, et al.
Published: (2025-01-01)