Based on CT scans at the 12th thoracic spine level, assessing the impact of skeletal muscle and adipose tissue index on one-year postoperative mortality in elderly hip fracture patients: a propensity score-matched multicenter retrospective study
Abstract Background Research has demonstrated that individuals with sarcopenia or sarcopenic obesity who experience fractures or undergo major surgical interventions exhibit a poorer prognosis compared to the general population. However, few studies have investigated the relationship between the ske...
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2025-01-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-024-08183-6 |
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| author | En-li Li Jia-sen Hu Zi-hao Chen Run-xun Ma Chen Jin Yi-tian Bu Si-xiang Feng Cheng-bin Huang Ya-ping Jin Lei Yang |
| author_facet | En-li Li Jia-sen Hu Zi-hao Chen Run-xun Ma Chen Jin Yi-tian Bu Si-xiang Feng Cheng-bin Huang Ya-ping Jin Lei Yang |
| author_sort | En-li Li |
| collection | DOAJ |
| description | Abstract Background Research has demonstrated that individuals with sarcopenia or sarcopenic obesity who experience fractures or undergo major surgical interventions exhibit a poorer prognosis compared to the general population. However, few studies have investigated the relationship between the skeletal muscle and adipose tissue indices, as measured at the 12th thoracic spine level, and adverse outcomes following orthopedic surgery. Therefore, this study aimed to prove whether skeletal muscle and adipose tissue index measured by computed tomography (CT) images based on a single layer are associated with one-year postoperative mortality in elderly hip fracture patients. Methods A total of 334 participants from two institutions were enrolled in this study to obtain skeletal muscle index (SMI), subcutaneous fat index (SFI), visceral fat index (VFI), and the visceral-to-subcutaneous ratio of the fat area (VSR) at T12 levels and divide them into death and survival groups based on the results of follow-up after 1 year. Propensity score matching (PSM) was employed to evaluate one-year postoperative mortality. Results Institution 1’s results identified that a lower SMI significantly heightened the risk of one-year postoperative mortality (OR = 0.799,95%CI 0.677–0.943, P = 0.008), making SMI an independent predictor. Institution 2’s results identified that age (OR = 1.081, 95%CI 1.005–1.163, P = 0.036), SMI (OR = 0.881, 95%CI 0.784–0.991, P = 0.035) as independent predictors of one-year postoperative mortality in elderly hip fracture. Receiver operator characteristics analysis revealed area under the curve (AUC) values for institution 1: SMI (0.738 (95%CI 0.626–0.851), significant), VFI (0.605 (95%CI 0.476–0.734)), VSR (0.583 (95%CI 0.451–0.715)); and for institution 2: SMI (0.742 (95%CI 0.612–0.872), significant) and Age (0.775 (95%CI 0.677–0.874), significant). Collectively, these results underscore that SMI serves as an independent predictor of one-year postoperative mortality in elderly hip fracture patients. Conclusion This study demonstrated that the T12-based SMI was independently associated with one-year mortality following hip fracture in geriatric patients, with lower preoperative SMI correlating with higher mortality rates post-surgery. |
| format | Article |
| id | doaj-art-51f9c773d0834adaabb445de9e4f32da |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-51f9c773d0834adaabb445de9e4f32da2025-01-12T12:04:42ZengBMCBMC Musculoskeletal Disorders1471-24742025-01-0126111010.1186/s12891-024-08183-6Based on CT scans at the 12th thoracic spine level, assessing the impact of skeletal muscle and adipose tissue index on one-year postoperative mortality in elderly hip fracture patients: a propensity score-matched multicenter retrospective studyEn-li Li0Jia-sen Hu1Zi-hao Chen2Run-xun Ma3Chen Jin4Yi-tian Bu5Si-xiang Feng6Cheng-bin Huang7Ya-ping Jin8Lei Yang9Department of Orthopedic, The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical UniversityYueqing People’s HospitalDepartment of Orthopedic, The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedic, The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedic, The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedic, The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedic, The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedic, The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical UniversityYueqing People’s HospitalDepartment of Orthopedic, The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical UniversityAbstract Background Research has demonstrated that individuals with sarcopenia or sarcopenic obesity who experience fractures or undergo major surgical interventions exhibit a poorer prognosis compared to the general population. However, few studies have investigated the relationship between the skeletal muscle and adipose tissue indices, as measured at the 12th thoracic spine level, and adverse outcomes following orthopedic surgery. Therefore, this study aimed to prove whether skeletal muscle and adipose tissue index measured by computed tomography (CT) images based on a single layer are associated with one-year postoperative mortality in elderly hip fracture patients. Methods A total of 334 participants from two institutions were enrolled in this study to obtain skeletal muscle index (SMI), subcutaneous fat index (SFI), visceral fat index (VFI), and the visceral-to-subcutaneous ratio of the fat area (VSR) at T12 levels and divide them into death and survival groups based on the results of follow-up after 1 year. Propensity score matching (PSM) was employed to evaluate one-year postoperative mortality. Results Institution 1’s results identified that a lower SMI significantly heightened the risk of one-year postoperative mortality (OR = 0.799,95%CI 0.677–0.943, P = 0.008), making SMI an independent predictor. Institution 2’s results identified that age (OR = 1.081, 95%CI 1.005–1.163, P = 0.036), SMI (OR = 0.881, 95%CI 0.784–0.991, P = 0.035) as independent predictors of one-year postoperative mortality in elderly hip fracture. Receiver operator characteristics analysis revealed area under the curve (AUC) values for institution 1: SMI (0.738 (95%CI 0.626–0.851), significant), VFI (0.605 (95%CI 0.476–0.734)), VSR (0.583 (95%CI 0.451–0.715)); and for institution 2: SMI (0.742 (95%CI 0.612–0.872), significant) and Age (0.775 (95%CI 0.677–0.874), significant). Collectively, these results underscore that SMI serves as an independent predictor of one-year postoperative mortality in elderly hip fracture patients. Conclusion This study demonstrated that the T12-based SMI was independently associated with one-year mortality following hip fracture in geriatric patients, with lower preoperative SMI correlating with higher mortality rates post-surgery.https://doi.org/10.1186/s12891-024-08183-6Hip fractureSkeletal muscle indexSarcopeniaComputed tomographyMortality |
| spellingShingle | En-li Li Jia-sen Hu Zi-hao Chen Run-xun Ma Chen Jin Yi-tian Bu Si-xiang Feng Cheng-bin Huang Ya-ping Jin Lei Yang Based on CT scans at the 12th thoracic spine level, assessing the impact of skeletal muscle and adipose tissue index on one-year postoperative mortality in elderly hip fracture patients: a propensity score-matched multicenter retrospective study BMC Musculoskeletal Disorders Hip fracture Skeletal muscle index Sarcopenia Computed tomography Mortality |
| title | Based on CT scans at the 12th thoracic spine level, assessing the impact of skeletal muscle and adipose tissue index on one-year postoperative mortality in elderly hip fracture patients: a propensity score-matched multicenter retrospective study |
| title_full | Based on CT scans at the 12th thoracic spine level, assessing the impact of skeletal muscle and adipose tissue index on one-year postoperative mortality in elderly hip fracture patients: a propensity score-matched multicenter retrospective study |
| title_fullStr | Based on CT scans at the 12th thoracic spine level, assessing the impact of skeletal muscle and adipose tissue index on one-year postoperative mortality in elderly hip fracture patients: a propensity score-matched multicenter retrospective study |
| title_full_unstemmed | Based on CT scans at the 12th thoracic spine level, assessing the impact of skeletal muscle and adipose tissue index on one-year postoperative mortality in elderly hip fracture patients: a propensity score-matched multicenter retrospective study |
| title_short | Based on CT scans at the 12th thoracic spine level, assessing the impact of skeletal muscle and adipose tissue index on one-year postoperative mortality in elderly hip fracture patients: a propensity score-matched multicenter retrospective study |
| title_sort | based on ct scans at the 12th thoracic spine level assessing the impact of skeletal muscle and adipose tissue index on one year postoperative mortality in elderly hip fracture patients a propensity score matched multicenter retrospective study |
| topic | Hip fracture Skeletal muscle index Sarcopenia Computed tomography Mortality |
| url | https://doi.org/10.1186/s12891-024-08183-6 |
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