Molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis: implications for endocrine health
BackgroundType 2 diabetes mellitus (T2DM) and osteoporosis are prevalent, interconnected chronic diseases that significantly impact global health. Understanding their complex biological relationship is crucial for improving patient outcomes and treatment strategies.MethodThis review examines recent...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1483512/full |
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| author | Liyun Jiang Xia Song Li Yan Yali Liu Xiumei Qiao Wen Zhang |
| author_facet | Liyun Jiang Xia Song Li Yan Yali Liu Xiumei Qiao Wen Zhang |
| author_sort | Liyun Jiang |
| collection | DOAJ |
| description | BackgroundType 2 diabetes mellitus (T2DM) and osteoporosis are prevalent, interconnected chronic diseases that significantly impact global health. Understanding their complex biological relationship is crucial for improving patient outcomes and treatment strategies.MethodThis review examines recent research on the mechanisms linking T2DM with osteoporosis. It focuses on how abnormalities in bone metabolism, autophagy, ferroptosis, and vitamin D receptor (VDR) gene polymorphisms contribute to osteoporosis in T2DM patients.ResultsOur analysis indicates that T2DM is associated with reduced bone formation and increased bone resorption, which are influenced by hormonal changes, inflammation, and disrupted cellular signaling pathways. Additionally, increased perirenal fat thickness worsens osteoporosis through local inflammation and altered adipokine levels. VDR gene polymorphisms provide new molecular insights into this connection.ConclusionAddressing the identified mechanisms with targeted management strategies may improve bone health in individuals with T2DM. Future research should explore these associations in greater detail to develop more effective prevention and treatment strategies. |
| format | Article |
| id | doaj-art-51d720e05127442c9d8208c497ed8a48 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-51d720e05127442c9d8208c497ed8a482025-01-17T05:10:10ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14835121483512Molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis: implications for endocrine healthLiyun Jiang0Xia Song1Li Yan2Yali Liu3Xiumei Qiao4Wen Zhang5Medical Laboratory Center, The First Hospital of Lanzhou University, Lanzhou, ChinaMedical Laboratory Center, The First Hospital of Lanzhou University, Lanzhou, ChinaMedical Laboratory Center, Gansu Provincial People’s Hospital, Lanzhou, ChinaMedical Laboratory Center, The First Hospital of Lanzhou University, Lanzhou, ChinaMedical Laboratory Center, The First Hospital of Lanzhou University, Lanzhou, ChinaMedical Laboratory Center, The First Hospital of Lanzhou University, Lanzhou, ChinaBackgroundType 2 diabetes mellitus (T2DM) and osteoporosis are prevalent, interconnected chronic diseases that significantly impact global health. Understanding their complex biological relationship is crucial for improving patient outcomes and treatment strategies.MethodThis review examines recent research on the mechanisms linking T2DM with osteoporosis. It focuses on how abnormalities in bone metabolism, autophagy, ferroptosis, and vitamin D receptor (VDR) gene polymorphisms contribute to osteoporosis in T2DM patients.ResultsOur analysis indicates that T2DM is associated with reduced bone formation and increased bone resorption, which are influenced by hormonal changes, inflammation, and disrupted cellular signaling pathways. Additionally, increased perirenal fat thickness worsens osteoporosis through local inflammation and altered adipokine levels. VDR gene polymorphisms provide new molecular insights into this connection.ConclusionAddressing the identified mechanisms with targeted management strategies may improve bone health in individuals with T2DM. Future research should explore these associations in greater detail to develop more effective prevention and treatment strategies.https://www.frontiersin.org/articles/10.3389/fendo.2024.1483512/fulltype 2 diabetes mellitusosteoporosisbone metabolismautophagyferroptosisperirenal fat thickness |
| spellingShingle | Liyun Jiang Xia Song Li Yan Yali Liu Xiumei Qiao Wen Zhang Molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis: implications for endocrine health Frontiers in Endocrinology type 2 diabetes mellitus osteoporosis bone metabolism autophagy ferroptosis perirenal fat thickness |
| title | Molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis: implications for endocrine health |
| title_full | Molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis: implications for endocrine health |
| title_fullStr | Molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis: implications for endocrine health |
| title_full_unstemmed | Molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis: implications for endocrine health |
| title_short | Molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis: implications for endocrine health |
| title_sort | molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis implications for endocrine health |
| topic | type 2 diabetes mellitus osteoporosis bone metabolism autophagy ferroptosis perirenal fat thickness |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1483512/full |
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