Segmentation aware probabilistic phenotyping of single-cell spatial protein expression data
Abstract Spatial protein expression technologies can map cellular content and organization by simultaneously quantifying the expression of >40 proteins at subcellular resolution within intact tissue sections and cell lines. However, necessary image segmentation to single cells is challenging and...
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Main Authors: | Yuju Lee, Edward L. Y. Chen, Darren C. H. Chan, Anuroopa Dinesh, Somaieh Afiuni-Zadeh, Conor Klamann, Alina Selega, Miralem Mrkonjic, Hartland W. Jackson, Kieran R. Campbell |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2025-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-55214-w |
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