SARS‐CoV‐2 spike protein enhances MAP4K3/GLK‐induced ACE2 stability in COVID‐19

SARS‐CoV‐2 spike protein enhances MAP4K3/GLK‐induced ACE2 stability in COVID‐19

Abstract ACE2 on epithelial cells is the SARS‐CoV‐2 entry receptor. Single‐cell RNA‐sequencing data derived from two COVID‐19 cohorts revealed that MAP4K3/GLK‐positive epithelial cells were increased in patients. SARS‐CoV‐2‐induced GLK overexpression in epithelial cells was correlated with COVID‐19...

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Main Authors: Huai‐Chia Chuang, Chia‐Hsin Hsueh, Pu‐Ming Hsu, Rou‐Huei Huang, Ching‐Yi Tsai, Nai‐Hsiang Chung, Yen‐Hung Chow, Tse‐Hua Tan
Format: Article
Language:English
Published: Springer Nature 2022-07-01
Series:EMBO Molecular Medicine
Subjects:
MAP4K3/GLK
ACE2
UBR4
SARS‐CoV‐2
COVID‐19
Online Access:https://doi.org/10.15252/emmm.202215904
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