Comparative study of liver injury protection by Akkermansia muciniphila and Faecalibacterium prausnitzii interventions in live and cell-free supernatant forms via targeting the hepcidin – ferroportin axis in mice with CCl₄-induced liver fibrosis

Comparative study of liver injury protection by Akkermansia muciniphila and Faecalibacterium prausnitzii interventions in live and cell-free supernatant forms via targeting the hepcidin – ferroportin axis in mice with CCl₄-induced liver fibrosis

Abstract Background liver fibrosis is associated with dysregulated iron homeostasis regulated by the hepcidin-ferroportin axis, and dysbiotic gut microbiota. This study aimed to investigate the preventive and ameliorative effects of live and cell-free supernatant (CFS) forms of Akkermansia muciniphi...

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Main Authors: Sara Ahmadi Badi, Hananeh Tavakoli Aval, Hamid Reza Moradi, Amin Malek, Seyed Amirhesam Seyedi, Mehdi Davari, Ahmad Bereimipour, Soghra Khani, Shohreh Khatami, Seyed Davar Siadat
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Gut Pathogens
Subjects:
Hepcidin
Ferroportin
Liver fibrosis
Akkermansia muciniphila
Faecalibacterium prausnitzii
Gut microbiota
Online Access:https://doi.org/10.1186/s13099-025-00728-x
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