Phosphorylated polysaccharides derived from Scrophulariae Radix mitigates lipopolysaccharide (LPS)-induced acute lung injury in mice by suppressing the NF-κB-mediated inflammatory response
Acute lung injury (ALI) is a severe form of diffuse lung disease that poses a significant health burden in clinical settings. Numerous natural compounds derived from plants have shown effective anti-inflammatory activities with low toxicity, particularly polysaccharides, which have garnered consider...
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Taylor & Francis Group
2024-12-01
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| Series: | Food and Agricultural Immunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09540105.2024.2442362 |
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| author | Lufen Huang Anguo Wu Jiaxue Chen Jiamin Zhu Xulong Qin Jianing Mi Bowen Wei Jianan Wang Yufeng Liu |
| author_facet | Lufen Huang Anguo Wu Jiaxue Chen Jiamin Zhu Xulong Qin Jianing Mi Bowen Wei Jianan Wang Yufeng Liu |
| author_sort | Lufen Huang |
| collection | DOAJ |
| description | Acute lung injury (ALI) is a severe form of diffuse lung disease that poses a significant health burden in clinical settings. Numerous natural compounds derived from plants have shown effective anti-inflammatory activities with low toxicity, particularly polysaccharides, which have garnered considerable attention. This study explores key aspects of the pathogenesis of ALI and the potential mitigation effects of phosphorylated polysaccharides derived from Scrophulariae Radix (PPSR) in a lipopolysaccharide (LPS)-induced mouse model of ALI. These include alterations in the lung tissue wet/dry ratio, histopathological changes, modulation of pro-inflammatory cytokines, and inhibition of the NF-κB signalling pathway. Moreover, PPSR significantly reduced lung nitric oxide (NO) production and the expression of inducible NO synthase (iNOS) in lung tissue. The findings provide important insights into the mechanisms underlying the therapeutic effects of PPSR, emphasising its anti-inflammatory properties and its potential to alleviate the detrimental consequences of ALI. |
| format | Article |
| id | doaj-art-51b5d08d54e1473f953a8b742709f88e |
| institution | Kabale University |
| issn | 0954-0105 1465-3443 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj-art-51b5d08d54e1473f953a8b742709f88e2024-12-20T03:35:56ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432024-12-0135110.1080/09540105.2024.2442362Phosphorylated polysaccharides derived from Scrophulariae Radix mitigates lipopolysaccharide (LPS)-induced acute lung injury in mice by suppressing the NF-κB-mediated inflammatory responseLufen Huang0Anguo Wu1Jiaxue Chen2Jiamin Zhu3Xulong Qin4Jianing Mi5Bowen Wei6Jianan Wang7Yufeng Liu8Department of Pharmacy, Jining Medical University, Rizhao, People’s Republic of ChinaSichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Department of Cardiology, the Affiliated Hospital of Southwest Medical University and Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, People's Republic of ChinaDepartment of Pharmacy, Jining Medical University, Rizhao, People’s Republic of ChinaDepartment of Pharmacy, Jining Medical University, Rizhao, People’s Republic of ChinaDepartment of Pharmacy, Jining Medical University, Rizhao, People’s Republic of ChinaState Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of ChinaDepartment of Pharmacy, Jining Medical University, Rizhao, People’s Republic of ChinaDepartment of Pharmacy, Jining Medical University, Rizhao, People’s Republic of ChinaDepartment of Pharmacy, Jining Medical University, Rizhao, People’s Republic of ChinaAcute lung injury (ALI) is a severe form of diffuse lung disease that poses a significant health burden in clinical settings. Numerous natural compounds derived from plants have shown effective anti-inflammatory activities with low toxicity, particularly polysaccharides, which have garnered considerable attention. This study explores key aspects of the pathogenesis of ALI and the potential mitigation effects of phosphorylated polysaccharides derived from Scrophulariae Radix (PPSR) in a lipopolysaccharide (LPS)-induced mouse model of ALI. These include alterations in the lung tissue wet/dry ratio, histopathological changes, modulation of pro-inflammatory cytokines, and inhibition of the NF-κB signalling pathway. Moreover, PPSR significantly reduced lung nitric oxide (NO) production and the expression of inducible NO synthase (iNOS) in lung tissue. The findings provide important insights into the mechanisms underlying the therapeutic effects of PPSR, emphasising its anti-inflammatory properties and its potential to alleviate the detrimental consequences of ALI.https://www.tandfonline.com/doi/10.1080/09540105.2024.2442362Phosphorylated polysaccharidesScrophulariae RadixPPSR acute lung injuryinflammatory responseNF-κB |
| spellingShingle | Lufen Huang Anguo Wu Jiaxue Chen Jiamin Zhu Xulong Qin Jianing Mi Bowen Wei Jianan Wang Yufeng Liu Phosphorylated polysaccharides derived from Scrophulariae Radix mitigates lipopolysaccharide (LPS)-induced acute lung injury in mice by suppressing the NF-κB-mediated inflammatory response Food and Agricultural Immunology Phosphorylated polysaccharides Scrophulariae Radix PPSR acute lung injury inflammatory response NF-κB |
| title | Phosphorylated polysaccharides derived from Scrophulariae Radix mitigates lipopolysaccharide (LPS)-induced acute lung injury in mice by suppressing the NF-κB-mediated inflammatory response |
| title_full | Phosphorylated polysaccharides derived from Scrophulariae Radix mitigates lipopolysaccharide (LPS)-induced acute lung injury in mice by suppressing the NF-κB-mediated inflammatory response |
| title_fullStr | Phosphorylated polysaccharides derived from Scrophulariae Radix mitigates lipopolysaccharide (LPS)-induced acute lung injury in mice by suppressing the NF-κB-mediated inflammatory response |
| title_full_unstemmed | Phosphorylated polysaccharides derived from Scrophulariae Radix mitigates lipopolysaccharide (LPS)-induced acute lung injury in mice by suppressing the NF-κB-mediated inflammatory response |
| title_short | Phosphorylated polysaccharides derived from Scrophulariae Radix mitigates lipopolysaccharide (LPS)-induced acute lung injury in mice by suppressing the NF-κB-mediated inflammatory response |
| title_sort | phosphorylated polysaccharides derived from scrophulariae radix mitigates lipopolysaccharide lps induced acute lung injury in mice by suppressing the nf κb mediated inflammatory response |
| topic | Phosphorylated polysaccharides Scrophulariae Radix PPSR acute lung injury inflammatory response NF-κB |
| url | https://www.tandfonline.com/doi/10.1080/09540105.2024.2442362 |
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