Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis Therapy
Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to joint inflammation, progressive tissue damage and significant disability, severely impacting patients’ quality of life. While the exact mechanisms underlying RA remain elusive, growing evidence suggests a strong link between int...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/12/1653 |
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| author | Vitaly Chasov Elvina Gilyazova Irina Ganeeva Ekaterina Zmievskaya Damir Davletshin Aygul Valiullina Emil Bulatov |
| author_facet | Vitaly Chasov Elvina Gilyazova Irina Ganeeva Ekaterina Zmievskaya Damir Davletshin Aygul Valiullina Emil Bulatov |
| author_sort | Vitaly Chasov |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to joint inflammation, progressive tissue damage and significant disability, severely impacting patients’ quality of life. While the exact mechanisms underlying RA remain elusive, growing evidence suggests a strong link between intestinal microbiota dysbiosis and the disease’s development and progression. Differences in microbial composition between healthy individuals and RA patients point to the role of gut microbiota in modulating immune responses and promoting inflammation. Therapies targeting microbiota restoration have demonstrated promise in improving treatment efficacy, enhancing patient outcomes and slowing disease progression. However, the complex interplay between gut microbiota and autoimmune pathways in RA requires further investigation to establish causative relationships and mechanisms. Here, we review the current understanding of the gut microbiota’s role in RA pathogenesis and its potential as a therapeutic target. |
| format | Article |
| id | doaj-art-51b0b27023bd4744b2aabf75b5a614e4 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-51b0b27023bd4744b2aabf75b5a614e42024-12-27T14:14:04ZengMDPI AGBiomolecules2218-273X2024-12-011412165310.3390/biom14121653Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis TherapyVitaly Chasov0Elvina Gilyazova1Irina Ganeeva2Ekaterina Zmievskaya3Damir Davletshin4Aygul Valiullina5Emil Bulatov6Laboratory of Biomedical Technologies, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, RussiaLaboratory of Biomedical Technologies, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, RussiaLaboratory of Biomedical Technologies, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, RussiaLaboratory of Biomedical Technologies, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, RussiaLaboratory of Biomedical Technologies, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, RussiaLaboratory of Biomedical Technologies, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, RussiaLaboratory of Biomedical Technologies, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, RussiaRheumatoid arthritis (RA) is a chronic autoimmune disease that leads to joint inflammation, progressive tissue damage and significant disability, severely impacting patients’ quality of life. While the exact mechanisms underlying RA remain elusive, growing evidence suggests a strong link between intestinal microbiota dysbiosis and the disease’s development and progression. Differences in microbial composition between healthy individuals and RA patients point to the role of gut microbiota in modulating immune responses and promoting inflammation. Therapies targeting microbiota restoration have demonstrated promise in improving treatment efficacy, enhancing patient outcomes and slowing disease progression. However, the complex interplay between gut microbiota and autoimmune pathways in RA requires further investigation to establish causative relationships and mechanisms. Here, we review the current understanding of the gut microbiota’s role in RA pathogenesis and its potential as a therapeutic target.https://www.mdpi.com/2218-273X/14/12/1653rheumatoid arthritisgut microbiotadysbiosisbacterial translocationmolecular mimicrybacterial metabolites |
| spellingShingle | Vitaly Chasov Elvina Gilyazova Irina Ganeeva Ekaterina Zmievskaya Damir Davletshin Aygul Valiullina Emil Bulatov Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis Therapy Biomolecules rheumatoid arthritis gut microbiota dysbiosis bacterial translocation molecular mimicry bacterial metabolites |
| title | Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis Therapy |
| title_full | Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis Therapy |
| title_fullStr | Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis Therapy |
| title_full_unstemmed | Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis Therapy |
| title_short | Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis Therapy |
| title_sort | gut microbiota modulation a novel strategy for rheumatoid arthritis therapy |
| topic | rheumatoid arthritis gut microbiota dysbiosis bacterial translocation molecular mimicry bacterial metabolites |
| url | https://www.mdpi.com/2218-273X/14/12/1653 |
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