Blue sclerae and their association with glaucoma (a review and case report)
<p> T.A. Beletskaya<sup>1,2</sup>, E.V. Kozina<sup>1</sup>, D.V. Dmitrenko<sup>1</sup>, Yu.I. Gavrilova<sup>2</sup> </p> <p> <sup>1</sup>Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Rus...
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| Format: | Article |
| Language: | Russian |
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Prime-Media
2023-11-01
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| Series: | РМЖ "Клиническая офтальмология" |
| Online Access: | http://clinopht.com/upload/iblock/634/g20ywl7zl2yu876ghxex4cr7f2sta4lh.pdf |
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| author | T.A. Beletskaya E.V. Kozina D.V. Dmitrenko Yu.I. Gavrilova |
| author_facet | T.A. Beletskaya E.V. Kozina D.V. Dmitrenko Yu.I. Gavrilova |
| author_sort | T.A. Beletskaya |
| collection | DOAJ |
| description | <p>
T.A. Beletskaya<sup>1,2</sup>, E.V. Kozina<sup>1</sup>, D.V. Dmitrenko<sup>1</sup>, Yu.I. Gavrilova<sup>2</sup>
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<p>
<sup>1</sup>Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation
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<p>
<sup>2</sup>Prof. P.G. Makarov Krasnoyarsk Regional Ophthalmological Clinical Hospital, Krasnoyarsk, Russian Federation
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<p>
This paper reviews the key risk factors and clinical manifestations of blue sclerae, which include a large group of diseases of various origins. Generally, this syndrome is genetically determined and is a constant phenotypic sign of osteogenesis imperfecta. In addition to the classic triad of blue sclera, brittle bones, and hearing loss, many authors refer glaucoma to as an ocular manifestation of brittle bone disease in addition to thin cornea and low corneoscleral rigidity. The combination of osteogenesis imperfecta type 1 and primary open-angle glaucoma is a novel phenotypic association. The most effective way of controlling intraocular pressure (IOP) in this condition is surgical intervention. Case report of a combination of glaucoma and syndromic connective tissue disease that appeared 15 years after the first visit to an ophthalmologist for recurrent ocular hypertension is presented. Selective laser trabeculoplasty and a fixed-dose combination of 0.3% bimatoprost and 0.5% timolol provided normal IOP levels. Ultrathin corneas and systemic hypotension do not rule out the need for further surgery.
</p>
<p>
<b>Keywords: </b>blue sclera, glaucoma, osteogenesis imperfecta, corneal thickness.
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<b>For citation:</b> Beletskaya T.A., Kozina E.V., Dmitrenko D.V., Gavrilova Yu.I. Blue sclerae and their association with glaucoma (a review and case report). Russian Journal of Clinical Ophthalmology. 2023;23(4):225–230 (in Russ.). DOI: 10.32364/2311-7729-2023-23-4-9.
</p> |
| format | Article |
| id | doaj-art-519d0da6500843c394db8d801f58ad63 |
| institution | Kabale University |
| issn | 2311-7729 2619-1571 |
| language | Russian |
| publishDate | 2023-11-01 |
| publisher | Prime-Media |
| record_format | Article |
| series | РМЖ "Клиническая офтальмология" |
| spelling | doaj-art-519d0da6500843c394db8d801f58ad632025-01-16T09:39:38ZrusPrime-MediaРМЖ "Клиническая офтальмология"2311-77292619-15712023-11-0123431667Blue sclerae and their association with glaucoma (a review and case report)T.A. Beletskaya0E.V. Kozina1D.V. Dmitrenko2Yu.I. Gavrilova3Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<p> T.A. Beletskaya<sup>1,2</sup>, E.V. Kozina<sup>1</sup>, D.V. Dmitrenko<sup>1</sup>, Yu.I. Gavrilova<sup>2</sup> </p> <p> <sup>1</sup>Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation </p> <p> <sup>2</sup>Prof. P.G. Makarov Krasnoyarsk Regional Ophthalmological Clinical Hospital, Krasnoyarsk, Russian Federation </p> <p> This paper reviews the key risk factors and clinical manifestations of blue sclerae, which include a large group of diseases of various origins. Generally, this syndrome is genetically determined and is a constant phenotypic sign of osteogenesis imperfecta. In addition to the classic triad of blue sclera, brittle bones, and hearing loss, many authors refer glaucoma to as an ocular manifestation of brittle bone disease in addition to thin cornea and low corneoscleral rigidity. The combination of osteogenesis imperfecta type 1 and primary open-angle glaucoma is a novel phenotypic association. The most effective way of controlling intraocular pressure (IOP) in this condition is surgical intervention. Case report of a combination of glaucoma and syndromic connective tissue disease that appeared 15 years after the first visit to an ophthalmologist for recurrent ocular hypertension is presented. Selective laser trabeculoplasty and a fixed-dose combination of 0.3% bimatoprost and 0.5% timolol provided normal IOP levels. Ultrathin corneas and systemic hypotension do not rule out the need for further surgery. </p> <p> <b>Keywords: </b>blue sclera, glaucoma, osteogenesis imperfecta, corneal thickness. </p> <p> <b>For citation:</b> Beletskaya T.A., Kozina E.V., Dmitrenko D.V., Gavrilova Yu.I. Blue sclerae and their association with glaucoma (a review and case report). Russian Journal of Clinical Ophthalmology. 2023;23(4):225–230 (in Russ.). DOI: 10.32364/2311-7729-2023-23-4-9. </p>http://clinopht.com/upload/iblock/634/g20ywl7zl2yu876ghxex4cr7f2sta4lh.pdf |
| spellingShingle | T.A. Beletskaya E.V. Kozina D.V. Dmitrenko Yu.I. Gavrilova Blue sclerae and their association with glaucoma (a review and case report) РМЖ "Клиническая офтальмология" |
| title | Blue sclerae and their association with glaucoma (a review and case report) |
| title_full | Blue sclerae and their association with glaucoma (a review and case report) |
| title_fullStr | Blue sclerae and their association with glaucoma (a review and case report) |
| title_full_unstemmed | Blue sclerae and their association with glaucoma (a review and case report) |
| title_short | Blue sclerae and their association with glaucoma (a review and case report) |
| title_sort | blue sclerae and their association with glaucoma a review and case report |
| url | http://clinopht.com/upload/iblock/634/g20ywl7zl2yu876ghxex4cr7f2sta4lh.pdf |
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