Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment
The therapeutic effect of immune checkpoint inhibitors (ICIs) in triple-negative breast cancer (TNBC) is unsatisfactory. The immune ''cold'' microenvironment caused by tumor-associated fibroblasts (TAFs) has an adverse effect on the antitumor response. Therefore, in this study, m...
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424005027 |
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| author | Nuo Cheng Qianqian Zhou Zongfang Jia Yang Mu Sheng Zhang Lei Wang Yunna Chen |
| author_facet | Nuo Cheng Qianqian Zhou Zongfang Jia Yang Mu Sheng Zhang Lei Wang Yunna Chen |
| author_sort | Nuo Cheng |
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| description | The therapeutic effect of immune checkpoint inhibitors (ICIs) in triple-negative breast cancer (TNBC) is unsatisfactory. The immune ''cold'' microenvironment caused by tumor-associated fibroblasts (TAFs) has an adverse effect on the antitumor response. Therefore, in this study, mixed cell membrane-coated porous magnetic nanoparticles (PMNPs) were constructed to deliver salvianolic acid B (SAB) to induce an antitumor immune response, facilitating the transition from a ''cold'' to a ''hot'' tumor and ultimately enhancing the therapeutic efficacy of immune checkpoint inhibitors. PMNP-SAB, which is based on a mixed coating of red blood cell membrane and TAF membrane (named PMNP-SAB@RTM), can simultaneously achieve the dual effects of ''immune escape'' and ''homologous targeting''. Under the influence of an external magnetic field (MF), SAB can be targeted and concentrated at the tumor site. The SAB released in tumors can effectively inhibit the production of extracellular matrix (ECM) by TAFs, promote T-cell infiltration, and induce antitumor immune responses. Ultimately, the combination of PMNP-SAB@RTM and BMS-1 (PD-1/PD-L1 inhibitor 1) effectively inhibited tumor growth. Finally, this study presents a precise and effective new strategy for TNBC immunotherapy on the basis of the differentiation of ''cold'' and ''hot'' microenvironments. |
| format | Article |
| id | doaj-art-5182e619f4c944b892b16e47fda5308f |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-5182e619f4c944b892b16e47fda5308f2025-01-17T04:52:14ZengElsevierMaterials Today Bio2590-00642025-02-0130101441Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatmentNuo Cheng0Qianqian Zhou1Zongfang Jia2Yang Mu3Sheng Zhang4Lei Wang5Yunna Chen6Anhui University of Chinese Medicine, Hefei, 230012, China; MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei, 230012, ChinaAnhui University of Chinese Medicine, Hefei, 230012, China; MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei, 230012, ChinaAnhui University of Chinese Medicine, Hefei, 230012, China; MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei, 230012, ChinaAnhui University of Chinese Medicine, Hefei, 230012, China; MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei, 230012, ChinaAnhui University of Chinese Medicine, Hefei, 230012, China; Corresponding author.Anhui University of Chinese Medicine, Hefei, 230012, China; MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei, 230012, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei, 230012, China; Corresponding author. Anhui University of Chinese Medicine, Hefei, 230012, China.Anhui University of Chinese Medicine, Hefei, 230012, China; Corresponding author.The therapeutic effect of immune checkpoint inhibitors (ICIs) in triple-negative breast cancer (TNBC) is unsatisfactory. The immune ''cold'' microenvironment caused by tumor-associated fibroblasts (TAFs) has an adverse effect on the antitumor response. Therefore, in this study, mixed cell membrane-coated porous magnetic nanoparticles (PMNPs) were constructed to deliver salvianolic acid B (SAB) to induce an antitumor immune response, facilitating the transition from a ''cold'' to a ''hot'' tumor and ultimately enhancing the therapeutic efficacy of immune checkpoint inhibitors. PMNP-SAB, which is based on a mixed coating of red blood cell membrane and TAF membrane (named PMNP-SAB@RTM), can simultaneously achieve the dual effects of ''immune escape'' and ''homologous targeting''. Under the influence of an external magnetic field (MF), SAB can be targeted and concentrated at the tumor site. The SAB released in tumors can effectively inhibit the production of extracellular matrix (ECM) by TAFs, promote T-cell infiltration, and induce antitumor immune responses. Ultimately, the combination of PMNP-SAB@RTM and BMS-1 (PD-1/PD-L1 inhibitor 1) effectively inhibited tumor growth. Finally, this study presents a precise and effective new strategy for TNBC immunotherapy on the basis of the differentiation of ''cold'' and ''hot'' microenvironments.http://www.sciencedirect.com/science/article/pii/S2590006424005027Triple negative breast cancerSalvianolic acid BTumor-associated fibroblastsImmune microenvironments |
| spellingShingle | Nuo Cheng Qianqian Zhou Zongfang Jia Yang Mu Sheng Zhang Lei Wang Yunna Chen Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment Materials Today Bio Triple negative breast cancer Salvianolic acid B Tumor-associated fibroblasts Immune microenvironments |
| title | Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment |
| title_full | Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment |
| title_fullStr | Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment |
| title_full_unstemmed | Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment |
| title_short | Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment |
| title_sort | functionalized biomimetic nanoparticles loaded with salvianolic acid b for synergistic targeted triple negative breast cancer treatment |
| topic | Triple negative breast cancer Salvianolic acid B Tumor-associated fibroblasts Immune microenvironments |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424005027 |
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