Dual-phase SilMA hydrogel: a dynamic scaffold for sequential drug release and enhanced spinal cord repair via neural differentiation and immunomodulation

Dual-phase SilMA hydrogel: a dynamic scaffold for sequential drug release and enhanced spinal cord repair via neural differentiation and immunomodulation

IntroductionSpinal cord injury (SCI) is a severe central nervous system disorder that results in significant sensory, motor, and autonomic dysfunctions. Current surgical techniques and high-dose hormone therapies have not achieved satisfactory clinical outcomes, highlighting the need for innovative...

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Main Authors: Ruizhi Zhang, Mingzhe Zhang, Lu Chen, Linlin Jiang, Chenbo Zou, Na Li, Hengxing Zhou, Shiqing Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
spinal cord injury
SilMA hydrogel
neurotrophin-3
angiotensin-(1–7)
immunomodulation
neural differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1501488/full
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