Bacterial Isolates and Their Antimicrobial Susceptibility Patterns Among Pediatric Patients with Urinary Tract Infections: A Retrospective Cross-Sectional Study at Tertiary Level in Afghanistan
Esmatullah Esmat,1 Ramin Saadaat,1 Noor Hassan Saedi,1 Ahmadullah Hakimi,1 Abdul Tawab Baryali,2 Abdul Jamil Rasooli,3 Sahar Noor,3 Maryam Ahmad,1 Ahmed Maseh Haidary1 1Department of Pathology and Clinical Laboratory, French Medical Institute for Mother and Children (FMIC), Kabul, Afghanistan; 2Depa...
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Dove Medical Press
2025-01-01
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| author | Esmat E Saadaat R Saedi NH Hakimi A Baryali AT Rasooli AJ Noor S Ahmad M Haidary AM |
| author_facet | Esmat E Saadaat R Saedi NH Hakimi A Baryali AT Rasooli AJ Noor S Ahmad M Haidary AM |
| author_sort | Esmat E |
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| description | Esmatullah Esmat,1 Ramin Saadaat,1 Noor Hassan Saedi,1 Ahmadullah Hakimi,1 Abdul Tawab Baryali,2 Abdul Jamil Rasooli,3 Sahar Noor,3 Maryam Ahmad,1 Ahmed Maseh Haidary1 1Department of Pathology and Clinical Laboratory, French Medical Institute for Mother and Children (FMIC), Kabul, Afghanistan; 2Department of Quality and Patient Safety, French Medical Institute for Mothers and Children (FMIC), Kabul, Afghanistan; 3Department of Paediatric Medicine, French Medical Institute for Mother and Children (FMIC), Kabul, AfghanistanCorrespondence: Ahmed Maseh Haidary, Department of Pathology and Clinical Laboratory, French Medical Institute for Mother and Children (FMIC), Behind Kabul Medical University, Kabul, PO, BOX:472, Afghanistan, Email ahmed.maseh9t9@gmail.comIntroduction: The widespread use of antibiotics is a serious and alarming situation in terms of the development of antimicrobial resistance. The current study was conducted to demonstrate the types of organism isolated from the urine of patients presenting with UTI symptoms as well as their antimicrobial sensitivity spectrum.Methodology: A descriptive cross-sectional study was conducted, and 272 positive urine cultures from children under 5 years of age with signs and symptoms of a UTI were included in the study. The types of organisms isolated from the urine cultures and their susceptibility to antibiotics were identified. The data collection form was designed as an Excel spreadsheet that included both dependent and independent variables, such as patient age, gender, WBC, red blood cell (RBC) count, nitrite, organism isolated, and antiprogram results.Results: Of the patients included, 64% were female. The majority were under one year of age, followed by children aged one to three. Among these children, 63% had pyuria and hematuria, and 64% had nitrite-positive urine samples. The most commonly isolated organisms included Escherichia coli, Klebsiella species, Candida species, Candida albicans, and Enterococcus species. In this study, 62% of gram-negative organisms were ESBL positive, among which the Proteus species demonstrated the highest ESBL positivity, followed by the Klebsiella species and E. coli. The majority of Enterobacteriaceae isolates in this study showed resistance to Augmentin and Ampicillin. Similarly, E. coli was highly resistant to third-generation cephalosporins, ceftazidime, and ceftriaxone.Conclusion: Due to the high prevalence of UTIs in pediatric patients and their nonspecific signs and symptoms, particularly in infants or young children, diagnosing and treating them, whilst difficult, is crucial. Urine samples should be analyzed for all pediatric patients with fever and, if pyuria is present, a urine culture is necessary.Keywords: bacterial isolates, antimicrobial susceptibility, pediatric patients, UTI |
| format | Article |
| id | doaj-art-51404b69b536481ebe7541d19e8ed1c5 |
| institution | Kabale University |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Infection and Drug Resistance |
| spelling | doaj-art-51404b69b536481ebe7541d19e8ed1c52025-01-12T16:52:41ZengDove Medical PressInfection and Drug Resistance1178-69732025-01-01Volume 18516099131Bacterial Isolates and Their Antimicrobial Susceptibility Patterns Among Pediatric Patients with Urinary Tract Infections: A Retrospective Cross-Sectional Study at Tertiary Level in AfghanistanEsmat ESaadaat RSaedi NHHakimi ABaryali ATRasooli AJNoor SAhmad MHaidary AMEsmatullah Esmat,1 Ramin Saadaat,1 Noor Hassan Saedi,1 Ahmadullah Hakimi,1 Abdul Tawab Baryali,2 Abdul Jamil Rasooli,3 Sahar Noor,3 Maryam Ahmad,1 Ahmed Maseh Haidary1 1Department of Pathology and Clinical Laboratory, French Medical Institute for Mother and Children (FMIC), Kabul, Afghanistan; 2Department of Quality and Patient Safety, French Medical Institute for Mothers and Children (FMIC), Kabul, Afghanistan; 3Department of Paediatric Medicine, French Medical Institute for Mother and Children (FMIC), Kabul, AfghanistanCorrespondence: Ahmed Maseh Haidary, Department of Pathology and Clinical Laboratory, French Medical Institute for Mother and Children (FMIC), Behind Kabul Medical University, Kabul, PO, BOX:472, Afghanistan, Email ahmed.maseh9t9@gmail.comIntroduction: The widespread use of antibiotics is a serious and alarming situation in terms of the development of antimicrobial resistance. The current study was conducted to demonstrate the types of organism isolated from the urine of patients presenting with UTI symptoms as well as their antimicrobial sensitivity spectrum.Methodology: A descriptive cross-sectional study was conducted, and 272 positive urine cultures from children under 5 years of age with signs and symptoms of a UTI were included in the study. The types of organisms isolated from the urine cultures and their susceptibility to antibiotics were identified. The data collection form was designed as an Excel spreadsheet that included both dependent and independent variables, such as patient age, gender, WBC, red blood cell (RBC) count, nitrite, organism isolated, and antiprogram results.Results: Of the patients included, 64% were female. The majority were under one year of age, followed by children aged one to three. Among these children, 63% had pyuria and hematuria, and 64% had nitrite-positive urine samples. The most commonly isolated organisms included Escherichia coli, Klebsiella species, Candida species, Candida albicans, and Enterococcus species. In this study, 62% of gram-negative organisms were ESBL positive, among which the Proteus species demonstrated the highest ESBL positivity, followed by the Klebsiella species and E. coli. The majority of Enterobacteriaceae isolates in this study showed resistance to Augmentin and Ampicillin. Similarly, E. coli was highly resistant to third-generation cephalosporins, ceftazidime, and ceftriaxone.Conclusion: Due to the high prevalence of UTIs in pediatric patients and their nonspecific signs and symptoms, particularly in infants or young children, diagnosing and treating them, whilst difficult, is crucial. Urine samples should be analyzed for all pediatric patients with fever and, if pyuria is present, a urine culture is necessary.Keywords: bacterial isolates, antimicrobial susceptibility, pediatric patients, UTIhttps://www.dovepress.com/bacterial-isolates-and-their-antimicrobial-susceptibility-patterns-amo-peer-reviewed-fulltext-article-IDRbacterial isolatesantimicrobial susceptibilitypediatric patientsuti |
| spellingShingle | Esmat E Saadaat R Saedi NH Hakimi A Baryali AT Rasooli AJ Noor S Ahmad M Haidary AM Bacterial Isolates and Their Antimicrobial Susceptibility Patterns Among Pediatric Patients with Urinary Tract Infections: A Retrospective Cross-Sectional Study at Tertiary Level in Afghanistan Infection and Drug Resistance bacterial isolates antimicrobial susceptibility pediatric patients uti |
| title | Bacterial Isolates and Their Antimicrobial Susceptibility Patterns Among Pediatric Patients with Urinary Tract Infections: A Retrospective Cross-Sectional Study at Tertiary Level in Afghanistan |
| title_full | Bacterial Isolates and Their Antimicrobial Susceptibility Patterns Among Pediatric Patients with Urinary Tract Infections: A Retrospective Cross-Sectional Study at Tertiary Level in Afghanistan |
| title_fullStr | Bacterial Isolates and Their Antimicrobial Susceptibility Patterns Among Pediatric Patients with Urinary Tract Infections: A Retrospective Cross-Sectional Study at Tertiary Level in Afghanistan |
| title_full_unstemmed | Bacterial Isolates and Their Antimicrobial Susceptibility Patterns Among Pediatric Patients with Urinary Tract Infections: A Retrospective Cross-Sectional Study at Tertiary Level in Afghanistan |
| title_short | Bacterial Isolates and Their Antimicrobial Susceptibility Patterns Among Pediatric Patients with Urinary Tract Infections: A Retrospective Cross-Sectional Study at Tertiary Level in Afghanistan |
| title_sort | bacterial isolates and their antimicrobial susceptibility patterns among pediatric patients with urinary tract infections a retrospective cross sectional study at tertiary level in afghanistan |
| topic | bacterial isolates antimicrobial susceptibility pediatric patients uti |
| url | https://www.dovepress.com/bacterial-isolates-and-their-antimicrobial-susceptibility-patterns-amo-peer-reviewed-fulltext-article-IDR |
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