Peripheral arterial pathology and osteoarthritis of the knee: US examination of arterial wall stiffness, thickness, and flow characteristics
Background: Osteoarthritis (OA) is a widespread chronic joint disorder characterized by the degeneration of articular cartilage, extensive bone remodeling, ligamentous fibrosis, and synovial inflammation impacting millions. Shared factors like phenotypic similarities, hypofibrinolysis, and inflammat...
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Elsevier
2024-12-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913124001043 |
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| author | Jon Olansen Minglang Yin Janine Molino Thomas Carruthers Derek Jenkins George Karniadakis Roy K. Aaron |
| author_facet | Jon Olansen Minglang Yin Janine Molino Thomas Carruthers Derek Jenkins George Karniadakis Roy K. Aaron |
| author_sort | Jon Olansen |
| collection | DOAJ |
| description | Background: Osteoarthritis (OA) is a widespread chronic joint disorder characterized by the degeneration of articular cartilage, extensive bone remodeling, ligamentous fibrosis, and synovial inflammation impacting millions. Shared factors like phenotypic similarities, hypofibrinolysis, and inflammation constitute similarities in pathophysiology and clinical manifestations between OA and peripheral vascular disease (PVD). This study investigated peripheral arterial flow characteristics, vascular wall thickness, and stiffness in knee OA to clarify a potential association with early atherosclerosis. Methods: The OA cohort consisted of 35 knees with a mean age of 69 years. The control cohort consisted of 58 knees with a mean age of 68 years. Subjects underwent arterial ultrasound scanning of the common femoral, superficial femoral, and popliteal arteries. Data measured included peak systolic volumetric flow, intima-media thickness, systolic and diastolic vessel diameter, and simultaneous EKG and flow curves. Structural and functional vascular data were quantified using the incremental Young's modulus, pulse wave velocity (PWV), and distensibility. Results: Significantly elevated arterial volumetric flow, measures of arterial stiffness, and intima-media wall thickness were observed in those with OA compared to those without. PWV as calculated by the Bramwell-Hill equation were found to be significantly greater in all three vessels of patients with OA. Conclusions: This study supports the association between peripheral arterial pathology and knee OA, consistent with shared clinical and phenotypic traits. The observed characteristics of early vascular pathology suggest potential pathophysiologic linkages between OA and PVD. This foundational framework provides avenues for mechanistic studies exploring the relationship between these two disease processes. |
| format | Article |
| id | doaj-art-512e90805c1a4f31b0ed9fb4d1ffaf62 |
| institution | Kabale University |
| issn | 2665-9131 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-512e90805c1a4f31b0ed9fb4d1ffaf622024-11-27T05:03:09ZengElsevierOsteoarthritis and Cartilage Open2665-91312024-12-0164100537Peripheral arterial pathology and osteoarthritis of the knee: US examination of arterial wall stiffness, thickness, and flow characteristicsJon Olansen0Minglang Yin1Janine Molino2Thomas Carruthers3Derek Jenkins4George Karniadakis5Roy K. Aaron6Department of Orthopedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA; Corresponding author. 2 Dudley St, Ste #200, Providence, RI 02903, USA.Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USADepartment of Orthopedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI 02903, USADivision of Vascular Surgery, Department of Surgery, Warren Alpert Medical School of Brown University, Providence, RI, USADepartment of Orthopedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI 02903, USADivision of Applied Mathematics, Brown University, Providence, RI 02912, USADepartment of Orthopedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI 02903, USABackground: Osteoarthritis (OA) is a widespread chronic joint disorder characterized by the degeneration of articular cartilage, extensive bone remodeling, ligamentous fibrosis, and synovial inflammation impacting millions. Shared factors like phenotypic similarities, hypofibrinolysis, and inflammation constitute similarities in pathophysiology and clinical manifestations between OA and peripheral vascular disease (PVD). This study investigated peripheral arterial flow characteristics, vascular wall thickness, and stiffness in knee OA to clarify a potential association with early atherosclerosis. Methods: The OA cohort consisted of 35 knees with a mean age of 69 years. The control cohort consisted of 58 knees with a mean age of 68 years. Subjects underwent arterial ultrasound scanning of the common femoral, superficial femoral, and popliteal arteries. Data measured included peak systolic volumetric flow, intima-media thickness, systolic and diastolic vessel diameter, and simultaneous EKG and flow curves. Structural and functional vascular data were quantified using the incremental Young's modulus, pulse wave velocity (PWV), and distensibility. Results: Significantly elevated arterial volumetric flow, measures of arterial stiffness, and intima-media wall thickness were observed in those with OA compared to those without. PWV as calculated by the Bramwell-Hill equation were found to be significantly greater in all three vessels of patients with OA. Conclusions: This study supports the association between peripheral arterial pathology and knee OA, consistent with shared clinical and phenotypic traits. The observed characteristics of early vascular pathology suggest potential pathophysiologic linkages between OA and PVD. This foundational framework provides avenues for mechanistic studies exploring the relationship between these two disease processes.http://www.sciencedirect.com/science/article/pii/S2665913124001043Vascular diseaseOsteoarthritisPulse wave velocityArterial stiffnessEndothelin |
| spellingShingle | Jon Olansen Minglang Yin Janine Molino Thomas Carruthers Derek Jenkins George Karniadakis Roy K. Aaron Peripheral arterial pathology and osteoarthritis of the knee: US examination of arterial wall stiffness, thickness, and flow characteristics Osteoarthritis and Cartilage Open Vascular disease Osteoarthritis Pulse wave velocity Arterial stiffness Endothelin |
| title | Peripheral arterial pathology and osteoarthritis of the knee: US examination of arterial wall stiffness, thickness, and flow characteristics |
| title_full | Peripheral arterial pathology and osteoarthritis of the knee: US examination of arterial wall stiffness, thickness, and flow characteristics |
| title_fullStr | Peripheral arterial pathology and osteoarthritis of the knee: US examination of arterial wall stiffness, thickness, and flow characteristics |
| title_full_unstemmed | Peripheral arterial pathology and osteoarthritis of the knee: US examination of arterial wall stiffness, thickness, and flow characteristics |
| title_short | Peripheral arterial pathology and osteoarthritis of the knee: US examination of arterial wall stiffness, thickness, and flow characteristics |
| title_sort | peripheral arterial pathology and osteoarthritis of the knee us examination of arterial wall stiffness thickness and flow characteristics |
| topic | Vascular disease Osteoarthritis Pulse wave velocity Arterial stiffness Endothelin |
| url | http://www.sciencedirect.com/science/article/pii/S2665913124001043 |
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