Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases
N7-methylguanosine (m7G) modification is one of the most prevalent forms of chemical modification in RNA molecules, which plays an important role in biological processes such as RNA stability, translation regulation and ribosome recognition. Methyl-transferation of m7G modification is catalyzed by t...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1491763/full |
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| author | Wenyan Zhou Yan Yi Wenyu Cao Xiaolin Zhong Ling Chen |
| author_facet | Wenyan Zhou Yan Yi Wenyu Cao Xiaolin Zhong Ling Chen |
| author_sort | Wenyan Zhou |
| collection | DOAJ |
| description | N7-methylguanosine (m7G) modification is one of the most prevalent forms of chemical modification in RNA molecules, which plays an important role in biological processes such as RNA stability, translation regulation and ribosome recognition. Methyl-transferation of m7G modification is catalyzed by the enzyme complex of methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4), and Quaking (QKI) recognizes internal m7G methylated mRNA and regulates mRNA translation and stabilization. Recent studies have found that m7G modification - related enzymes are associated with the onset and progression of digestive cancer, such as colorectal cancer, liver cancer, and other digestive diseases such as ulcerative colitis. This review will focus on the latest research progress on the roles of m7G methyltransferase METTL1/WDR4 and recognized enzyme QKI in digestive diseases. |
| format | Article |
| id | doaj-art-51121fe74a7743079322396383fccffb |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-51121fe74a7743079322396383fccffb2025-01-09T06:10:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14917631491763Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseasesWenyan Zhou0Yan Yi1Wenyu Cao2Xiaolin Zhong3Ling Chen4Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaInstitute Center of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaClinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaN7-methylguanosine (m7G) modification is one of the most prevalent forms of chemical modification in RNA molecules, which plays an important role in biological processes such as RNA stability, translation regulation and ribosome recognition. Methyl-transferation of m7G modification is catalyzed by the enzyme complex of methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4), and Quaking (QKI) recognizes internal m7G methylated mRNA and regulates mRNA translation and stabilization. Recent studies have found that m7G modification - related enzymes are associated with the onset and progression of digestive cancer, such as colorectal cancer, liver cancer, and other digestive diseases such as ulcerative colitis. This review will focus on the latest research progress on the roles of m7G methyltransferase METTL1/WDR4 and recognized enzyme QKI in digestive diseases.https://www.frontiersin.org/articles/10.3389/fphar.2024.1491763/fullm7GMETTL1WDR4QKIcancerdigestive diseases |
| spellingShingle | Wenyan Zhou Yan Yi Wenyu Cao Xiaolin Zhong Ling Chen Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases Frontiers in Pharmacology m7G METTL1 WDR4 QKI cancer digestive diseases |
| title | Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases |
| title_full | Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases |
| title_fullStr | Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases |
| title_full_unstemmed | Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases |
| title_short | Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases |
| title_sort | functions of mettl1 wdr4 and qki as m7g modification related enzymes in digestive diseases |
| topic | m7G METTL1 WDR4 QKI cancer digestive diseases |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1491763/full |
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