Mechanisms of delayed ischemia/reperfusion evoked ROS generation in the hippocampal CA1 zone of adult mouse brain slices

Mechanisms of delayed ischemia/reperfusion evoked ROS generation in the hippocampal CA1 zone of adult mouse brain slices

Abstract ROS overproduction is an important contributor to delayed ischemia/reperfusion induced neuronal injury, but relevant mechanisms remain poorly understood. We used oxygen–glucose deprivation (OGD)/reperfusion in mouse hippocampal slices to investigate ROS production in the CA1 pyramidal cell...

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Bibliographic Details
Main Authors: Yuliya V. Medvedeva, Edward Sharman, John H. Weiss
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Hippocampal slice
Mitochondria
Mitochondrial hyperpolarization
Zn2+
MCU
Oxygen glucose deprivation
Online Access:https://doi.org/10.1038/s41598-025-07070-x
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