Roles of the gut microbiota in human neurodevelopment and adult brain disorders
Growing evidence demonstrates the connection between gut microbiota, neurodevelopment, and adult brain function. Microbial colonization occurs before the maturation of neural systems and its association with brain development. The early microbiome interactions with the gut-brain axis evolved to stim...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1446700/full |
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| author | Rahul Mallick Sanjay Basak Ranjit K. Das Antara Banerjee Sujay Paul Surajit Pathak Asim K. Duttaroy |
| author_facet | Rahul Mallick Sanjay Basak Ranjit K. Das Antara Banerjee Sujay Paul Surajit Pathak Asim K. Duttaroy |
| author_sort | Rahul Mallick |
| collection | DOAJ |
| description | Growing evidence demonstrates the connection between gut microbiota, neurodevelopment, and adult brain function. Microbial colonization occurs before the maturation of neural systems and its association with brain development. The early microbiome interactions with the gut-brain axis evolved to stimulate cognitive activities. Gut dysbiosis can lead to impaired brain development, growth, and function. Docosahexaenoic acid (DHA) is critically required for brain structure and function, modulates gut microbiota, and impacts brain activity. This review explores how gut microbiota influences early brain development and adult functions, encompassing the modulation of neurotransmitter activity, neuroinflammation, and blood-brain barrier integrity. In addition, it highlights processes of how the gut microbiome affects fetal neurodevelopment and discusses adult brain disorders. |
| format | Article |
| id | doaj-art-50f1a0c32d5d4ebab55aea02da03bee8 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-50f1a0c32d5d4ebab55aea02da03bee82024-11-26T06:26:28ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-11-011810.3389/fnins.2024.14467001446700Roles of the gut microbiota in human neurodevelopment and adult brain disordersRahul Mallick0Sanjay Basak1Ranjit K. Das2Antara Banerjee3Sujay Paul4Surajit Pathak5Asim K. Duttaroy6A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandMolecular Biology Division, ICMR-National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, IndiaDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, United StatesFaculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chennai, IndiaTecnologico de Monterrey, School of Engineering and Sciences, Queretaro, MexicoFaculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chennai, IndiaDepartment of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, NorwayGrowing evidence demonstrates the connection between gut microbiota, neurodevelopment, and adult brain function. Microbial colonization occurs before the maturation of neural systems and its association with brain development. The early microbiome interactions with the gut-brain axis evolved to stimulate cognitive activities. Gut dysbiosis can lead to impaired brain development, growth, and function. Docosahexaenoic acid (DHA) is critically required for brain structure and function, modulates gut microbiota, and impacts brain activity. This review explores how gut microbiota influences early brain development and adult functions, encompassing the modulation of neurotransmitter activity, neuroinflammation, and blood-brain barrier integrity. In addition, it highlights processes of how the gut microbiome affects fetal neurodevelopment and discusses adult brain disorders.https://www.frontiersin.org/articles/10.3389/fnins.2024.1446700/fullgut microbiotabrain developmentbrain functiondysbiosisdrugsDHA |
| spellingShingle | Rahul Mallick Sanjay Basak Ranjit K. Das Antara Banerjee Sujay Paul Surajit Pathak Asim K. Duttaroy Roles of the gut microbiota in human neurodevelopment and adult brain disorders Frontiers in Neuroscience gut microbiota brain development brain function dysbiosis drugs DHA |
| title | Roles of the gut microbiota in human neurodevelopment and adult brain disorders |
| title_full | Roles of the gut microbiota in human neurodevelopment and adult brain disorders |
| title_fullStr | Roles of the gut microbiota in human neurodevelopment and adult brain disorders |
| title_full_unstemmed | Roles of the gut microbiota in human neurodevelopment and adult brain disorders |
| title_short | Roles of the gut microbiota in human neurodevelopment and adult brain disorders |
| title_sort | roles of the gut microbiota in human neurodevelopment and adult brain disorders |
| topic | gut microbiota brain development brain function dysbiosis drugs DHA |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1446700/full |
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