Outcome prediction using sequential organ failure assessment (SOFA) score and serum lactate levels in organophosphate poisoning
Background: Organophosphorus compounds are widely used as pesticides in agriculture practicing countries like India. Since it is readily available and accessible, it is one of the most commonly used agents for suicidal poisoning. The current study was undertaken to evaluate the performance of the SO...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-04-01
|
| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_1713_22 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846170895132917760 |
|---|---|
| author | Govinda Balmuchu Manoj K. Mohanty Manas R. Sahu Upendra Hansda Alagarasan Naveen Preetam K. Lenka |
| author_facet | Govinda Balmuchu Manoj K. Mohanty Manas R. Sahu Upendra Hansda Alagarasan Naveen Preetam K. Lenka |
| author_sort | Govinda Balmuchu |
| collection | DOAJ |
| description | Background:
Organophosphorus compounds are widely used as pesticides in agriculture practicing countries like India. Since it is readily available and accessible, it is one of the most commonly used agents for suicidal poisoning. The current study was undertaken to evaluate the performance of the SOFA score (scoring system) and the serum lactate level (laboratory parameter) as a mortality predictor in organophosphorus poisoning.
Material and Methods:
This prospective observational study was conducted at AIIMS, Bhubaneswar, for 17 months. The study population included all patients with an alleged history of ingestion of organophosphorus (OP) compounds reporting to the casualty. The receiver operating characteristic (ROC) curve and the logistic regression analysis were used for the analysis.
Results:
In our study, 75 patients with OP poisoning were studied after satisfying the inclusion criteria. OP poisoning was commonly seen in married males aged 21–40 years. Twelve (16%) patients died during the process of treatment. There was a statistically significant difference in the mean SOFA score, serum lactate level, pH value, and mean duration of hospital stay between the discharged and the deceased patients. In the current study, the ROC curve analysis used to assess the predictor of the outcome of OP poisoning showed that the area under the curve for SOFA score and serum lactate level were 0.794 (95% CI 0.641–0.948) and 0.659 (95% CI 0.472–0.847), respectively.
Conclusion:
Sequential Organ Failure Assessment (SOFA) score is significantly associated with the outcome of organophosphate poisoning and can be utilized to predict mortality. |
| format | Article |
| id | doaj-art-50f1a0a9810047b0a196addbb7e72406 |
| institution | Kabale University |
| issn | 2249-4863 2278-7135 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj-art-50f1a0a9810047b0a196addbb7e724062024-11-11T11:07:37ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352023-04-0112477778210.4103/jfmpc.jfmpc_1713_22Outcome prediction using sequential organ failure assessment (SOFA) score and serum lactate levels in organophosphate poisoningGovinda BalmuchuManoj K. MohantyManas R. SahuUpendra HansdaAlagarasan NaveenPreetam K. LenkaBackground: Organophosphorus compounds are widely used as pesticides in agriculture practicing countries like India. Since it is readily available and accessible, it is one of the most commonly used agents for suicidal poisoning. The current study was undertaken to evaluate the performance of the SOFA score (scoring system) and the serum lactate level (laboratory parameter) as a mortality predictor in organophosphorus poisoning. Material and Methods: This prospective observational study was conducted at AIIMS, Bhubaneswar, for 17 months. The study population included all patients with an alleged history of ingestion of organophosphorus (OP) compounds reporting to the casualty. The receiver operating characteristic (ROC) curve and the logistic regression analysis were used for the analysis. Results: In our study, 75 patients with OP poisoning were studied after satisfying the inclusion criteria. OP poisoning was commonly seen in married males aged 21–40 years. Twelve (16%) patients died during the process of treatment. There was a statistically significant difference in the mean SOFA score, serum lactate level, pH value, and mean duration of hospital stay between the discharged and the deceased patients. In the current study, the ROC curve analysis used to assess the predictor of the outcome of OP poisoning showed that the area under the curve for SOFA score and serum lactate level were 0.794 (95% CI 0.641–0.948) and 0.659 (95% CI 0.472–0.847), respectively. Conclusion: Sequential Organ Failure Assessment (SOFA) score is significantly associated with the outcome of organophosphate poisoning and can be utilized to predict mortality.https://journals.lww.com/10.4103/jfmpc.jfmpc_1713_22lactatemortalityorganophosphate poisoningorganophosphorus compoundsofa score |
| spellingShingle | Govinda Balmuchu Manoj K. Mohanty Manas R. Sahu Upendra Hansda Alagarasan Naveen Preetam K. Lenka Outcome prediction using sequential organ failure assessment (SOFA) score and serum lactate levels in organophosphate poisoning Journal of Family Medicine and Primary Care lactate mortality organophosphate poisoning organophosphorus compound sofa score |
| title | Outcome prediction using sequential organ failure assessment (SOFA) score and serum lactate levels in organophosphate poisoning |
| title_full | Outcome prediction using sequential organ failure assessment (SOFA) score and serum lactate levels in organophosphate poisoning |
| title_fullStr | Outcome prediction using sequential organ failure assessment (SOFA) score and serum lactate levels in organophosphate poisoning |
| title_full_unstemmed | Outcome prediction using sequential organ failure assessment (SOFA) score and serum lactate levels in organophosphate poisoning |
| title_short | Outcome prediction using sequential organ failure assessment (SOFA) score and serum lactate levels in organophosphate poisoning |
| title_sort | outcome prediction using sequential organ failure assessment sofa score and serum lactate levels in organophosphate poisoning |
| topic | lactate mortality organophosphate poisoning organophosphorus compound sofa score |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_1713_22 |
| work_keys_str_mv | AT govindabalmuchu outcomepredictionusingsequentialorganfailureassessmentsofascoreandserumlactatelevelsinorganophosphatepoisoning AT manojkmohanty outcomepredictionusingsequentialorganfailureassessmentsofascoreandserumlactatelevelsinorganophosphatepoisoning AT manasrsahu outcomepredictionusingsequentialorganfailureassessmentsofascoreandserumlactatelevelsinorganophosphatepoisoning AT upendrahansda outcomepredictionusingsequentialorganfailureassessmentsofascoreandserumlactatelevelsinorganophosphatepoisoning AT alagarasannaveen outcomepredictionusingsequentialorganfailureassessmentsofascoreandserumlactatelevelsinorganophosphatepoisoning AT preetamklenka outcomepredictionusingsequentialorganfailureassessmentsofascoreandserumlactatelevelsinorganophosphatepoisoning |