The Effects of Carbonate on Candida albicans Filamentation, Biofilm Formation, and Antifungal Resistance
ABSTRACT Candida albicans, a member of the normal microbial population of healthy humans, is an opportunistic pathogen that can cause serious disease in immunocompromised patients. An important virulence factor of C. albicans is the formation of biofilms. These organized communities of cells are eff...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | MicrobiologyOpen |
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| Online Access: | https://doi.org/10.1002/mbo3.70008 |
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| author | Trenton P. Miedema Kayla E. Grooters Ian A. Cleary |
| author_facet | Trenton P. Miedema Kayla E. Grooters Ian A. Cleary |
| author_sort | Trenton P. Miedema |
| collection | DOAJ |
| description | ABSTRACT Candida albicans, a member of the normal microbial population of healthy humans, is an opportunistic pathogen that can cause serious disease in immunocompromised patients. An important virulence factor of C. albicans is the formation of biofilms. These organized communities of cells are efficient at attaching to host cells and implanted medical devices. Carbonate has been studied as an agricultural antifungal agent, and here we demonstrate that carbonate can affect filamentation, biofilm formation, and antifungal drug resistance in C. albicans. |
| format | Article |
| id | doaj-art-50b07ad301c747c4a0a3fa7a699eafeb |
| institution | Kabale University |
| issn | 2045-8827 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | MicrobiologyOpen |
| spelling | doaj-art-50b07ad301c747c4a0a3fa7a699eafeb2024-12-27T08:33:05ZengWileyMicrobiologyOpen2045-88272024-12-01136n/an/a10.1002/mbo3.70008The Effects of Carbonate on Candida albicans Filamentation, Biofilm Formation, and Antifungal ResistanceTrenton P. Miedema0Kayla E. Grooters1Ian A. Cleary2Department of Biomedical Sciences Grand Valley State University Allendale Michigan USADepartment of Biomedical Sciences Grand Valley State University Allendale Michigan USADepartment of Biomedical Sciences Grand Valley State University Allendale Michigan USAABSTRACT Candida albicans, a member of the normal microbial population of healthy humans, is an opportunistic pathogen that can cause serious disease in immunocompromised patients. An important virulence factor of C. albicans is the formation of biofilms. These organized communities of cells are efficient at attaching to host cells and implanted medical devices. Carbonate has been studied as an agricultural antifungal agent, and here we demonstrate that carbonate can affect filamentation, biofilm formation, and antifungal drug resistance in C. albicans.https://doi.org/10.1002/mbo3.70008antifungalsCandida albicanscarbonatefilamentation |
| spellingShingle | Trenton P. Miedema Kayla E. Grooters Ian A. Cleary The Effects of Carbonate on Candida albicans Filamentation, Biofilm Formation, and Antifungal Resistance MicrobiologyOpen antifungals Candida albicans carbonate filamentation |
| title | The Effects of Carbonate on Candida albicans Filamentation, Biofilm Formation, and Antifungal Resistance |
| title_full | The Effects of Carbonate on Candida albicans Filamentation, Biofilm Formation, and Antifungal Resistance |
| title_fullStr | The Effects of Carbonate on Candida albicans Filamentation, Biofilm Formation, and Antifungal Resistance |
| title_full_unstemmed | The Effects of Carbonate on Candida albicans Filamentation, Biofilm Formation, and Antifungal Resistance |
| title_short | The Effects of Carbonate on Candida albicans Filamentation, Biofilm Formation, and Antifungal Resistance |
| title_sort | effects of carbonate on candida albicans filamentation biofilm formation and antifungal resistance |
| topic | antifungals Candida albicans carbonate filamentation |
| url | https://doi.org/10.1002/mbo3.70008 |
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