Hydroxychloroquine’s Early Impact on Cone Density
Purpose. To evaluate early effects of hydroxychloroquine (HCQ) on the retina using adaptive optics (AO). Methods. This was a prospective observational single-center study of 29 eyes of 29 patients who had been treated with HCQ for the first time and followed with AO for a minimum of two years. Cone...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2021/1389805 |
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| author | Tomoko Ueda-Consolvo Toshihiko Oiwake Shinya Abe Tomoko Nakamura Ayaka Numata Atsushi Hayashi |
| author_facet | Tomoko Ueda-Consolvo Toshihiko Oiwake Shinya Abe Tomoko Nakamura Ayaka Numata Atsushi Hayashi |
| author_sort | Tomoko Ueda-Consolvo |
| collection | DOAJ |
| description | Purpose. To evaluate early effects of hydroxychloroquine (HCQ) on the retina using adaptive optics (AO). Methods. This was a prospective observational single-center study of 29 eyes of 29 patients who had been treated with HCQ for the first time and followed with AO for a minimum of two years. Cone counting was performed in 4 quadrants, nasal, temporal, superior, and inferior, at 0.75 mm from the foveal center. The changes of cone density on AO, visual acuity, and foveal thickness within two years of use were analyzed. The changes of mean cone density of patients whose cumulative dose was over 200 g in 2 years were also assessed. We evaluated the correlation between cone density and cumulative dose of HCQ. Results. There was no significant decrease in cone density in the first 2 years of HCQ use. VA and foveal thickness did not show obvious change, either. Among 9 patients whose cumulative dose was over 200 g in 2 years, the mean cone density showed no significant change at 6, 12, 18, and 24 months compared with baseline (P=0.381, P=0.380, P=0.281, and P=0.534, respectively). There was no correlation between cone density and cumulative dose of HCQ at two years (Spearman’s correlation coefficient, r = −0.0553, P=0.780; n = 29). Conclusion. AO showed no change in cone density in the first two years of HCQ use. |
| format | Article |
| id | doaj-art-507a412a3fb6482697ce6934505af175 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-507a412a3fb6482697ce6934505af1752025-02-03T05:47:39ZengWileyJournal of Ophthalmology2090-004X2090-00582021-01-01202110.1155/2021/13898051389805Hydroxychloroquine’s Early Impact on Cone DensityTomoko Ueda-Consolvo0Toshihiko Oiwake1Shinya Abe2Tomoko Nakamura3Ayaka Numata4Atsushi Hayashi5Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanPurpose. To evaluate early effects of hydroxychloroquine (HCQ) on the retina using adaptive optics (AO). Methods. This was a prospective observational single-center study of 29 eyes of 29 patients who had been treated with HCQ for the first time and followed with AO for a minimum of two years. Cone counting was performed in 4 quadrants, nasal, temporal, superior, and inferior, at 0.75 mm from the foveal center. The changes of cone density on AO, visual acuity, and foveal thickness within two years of use were analyzed. The changes of mean cone density of patients whose cumulative dose was over 200 g in 2 years were also assessed. We evaluated the correlation between cone density and cumulative dose of HCQ. Results. There was no significant decrease in cone density in the first 2 years of HCQ use. VA and foveal thickness did not show obvious change, either. Among 9 patients whose cumulative dose was over 200 g in 2 years, the mean cone density showed no significant change at 6, 12, 18, and 24 months compared with baseline (P=0.381, P=0.380, P=0.281, and P=0.534, respectively). There was no correlation between cone density and cumulative dose of HCQ at two years (Spearman’s correlation coefficient, r = −0.0553, P=0.780; n = 29). Conclusion. AO showed no change in cone density in the first two years of HCQ use.http://dx.doi.org/10.1155/2021/1389805 |
| spellingShingle | Tomoko Ueda-Consolvo Toshihiko Oiwake Shinya Abe Tomoko Nakamura Ayaka Numata Atsushi Hayashi Hydroxychloroquine’s Early Impact on Cone Density Journal of Ophthalmology |
| title | Hydroxychloroquine’s Early Impact on Cone Density |
| title_full | Hydroxychloroquine’s Early Impact on Cone Density |
| title_fullStr | Hydroxychloroquine’s Early Impact on Cone Density |
| title_full_unstemmed | Hydroxychloroquine’s Early Impact on Cone Density |
| title_short | Hydroxychloroquine’s Early Impact on Cone Density |
| title_sort | hydroxychloroquine s early impact on cone density |
| url | http://dx.doi.org/10.1155/2021/1389805 |
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