Low‐dimensional neural ordinary differential equations accounting for inter‐individual variability implemented in Monolix and NONMEM
Abstract Neural ordinary differential equations (NODEs) are an emerging machine learning (ML) method to model pharmacometric (PMX) data. Combining mechanism‐based components to describe “known parts” and neural networks to learn “unknown parts” is a promising ML‐based PMX approach. In this work, the...
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Main Authors: | Dominic Stefan Bräm, Bernhard Steiert, Marc Pfister, Britta Steffens, Gilbert Koch |
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Format: | Article |
Language: | English |
Published: |
Wiley
2025-01-01
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Series: | CPT: Pharmacometrics & Systems Pharmacology |
Online Access: | https://doi.org/10.1002/psp4.13265 |
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