Promising cell systems for targeted delivery of nano- and microcarriers loaded with drugs or biomolecules (review)
Introduction. Cellular systems for targeted delivery of drug and biological molecules (drug delivery systems, DDSs) are currently considered as a promising solution to the problems of nano- and micro-sized drug carriers.Text. The review briefly examines fundamental and applied issues in the developm...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2024-11-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/1974 |
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| author | L. A. Miroshnichenko T. Yu. Polyakova I. A. Khlusov E. Yu. Avdeeva V. G. Luzhanin E. I. Molokhova A. L. Golovanenko M. Yu. Khlusova M. V. Belousov |
| author_facet | L. A. Miroshnichenko T. Yu. Polyakova I. A. Khlusov E. Yu. Avdeeva V. G. Luzhanin E. I. Molokhova A. L. Golovanenko M. Yu. Khlusova M. V. Belousov |
| author_sort | L. A. Miroshnichenko |
| collection | DOAJ |
| description | Introduction. Cellular systems for targeted delivery of drug and biological molecules (drug delivery systems, DDSs) are currently considered as a promising solution to the problems of nano- and micro-sized drug carriers.Text. The review briefly examines fundamental and applied issues in the development of cellular DDSs, the morphofunctional diversity of which theoretically makes it possible to solve the problems of pharmacotherapy of various diseases. Sources are presented summarizing clinical protocols for the use of cellular DDSs, which are, however, limited to antitumor and anti-inflammatory therapy. The advantages, as well as particular and general disadvantages of using certain cells (blood cells, immunocytes, stem cells) as promising platforms for translation into clinical practice of delivery vehicles for various drugs (antibiotics, cytostatics, monoclonal antibodies, enzymes, etc.) loaded into nano- and micro-sized DDSs.Conclusion. Despite the obvious and impressive successes of fundamental and applied research in this area, a difficult path lies ahead in optimizing the processes of targeted delivery and controlled release of drug and biological molecules using cellular DDSs. |
| format | Article |
| id | doaj-art-5028448e902b4516b2dc8f1a2eebe07c |
| institution | Kabale University |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2024-11-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-5028448e902b4516b2dc8f1a2eebe07c2025-08-20T03:59:04ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492024-11-01134455910.33380/2305-2066-2024-13-4-18971302Promising cell systems for targeted delivery of nano- and microcarriers loaded with drugs or biomolecules (review)L. A. Miroshnichenko0T. Yu. Polyakova1I. A. Khlusov2E. Yu. Avdeeva3V. G. Luzhanin4E. I. Molokhova5A. L. Golovanenko6M. Yu. Khlusova7M. V. Belousov8Siberian State Medical University, SSMUSiberian State Medical University, SSMUSiberian State Medical University, SSMUSiberian State Medical University, SSMUFederal State Budgetary Educational Institution of Higher Education "Perm State Pharmaceutical Academy" of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education "Perm State Pharmaceutical Academy" of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education "Perm State Pharmaceutical Academy" of the Ministry of Health of the Russian FederationSiberian State Medical University, SSMUSiberian State Medical University, SSMUIntroduction. Cellular systems for targeted delivery of drug and biological molecules (drug delivery systems, DDSs) are currently considered as a promising solution to the problems of nano- and micro-sized drug carriers.Text. The review briefly examines fundamental and applied issues in the development of cellular DDSs, the morphofunctional diversity of which theoretically makes it possible to solve the problems of pharmacotherapy of various diseases. Sources are presented summarizing clinical protocols for the use of cellular DDSs, which are, however, limited to antitumor and anti-inflammatory therapy. The advantages, as well as particular and general disadvantages of using certain cells (blood cells, immunocytes, stem cells) as promising platforms for translation into clinical practice of delivery vehicles for various drugs (antibiotics, cytostatics, monoclonal antibodies, enzymes, etc.) loaded into nano- and micro-sized DDSs.Conclusion. Despite the obvious and impressive successes of fundamental and applied research in this area, a difficult path lies ahead in optimizing the processes of targeted delivery and controlled release of drug and biological molecules using cellular DDSs.https://www.pharmjournal.ru/jour/article/view/1974targeted delivery of drugs and biomoleculescellular platformsachievementsproblems |
| spellingShingle | L. A. Miroshnichenko T. Yu. Polyakova I. A. Khlusov E. Yu. Avdeeva V. G. Luzhanin E. I. Molokhova A. L. Golovanenko M. Yu. Khlusova M. V. Belousov Promising cell systems for targeted delivery of nano- and microcarriers loaded with drugs or biomolecules (review) Разработка и регистрация лекарственных средств targeted delivery of drugs and biomolecules cellular platforms achievements problems |
| title | Promising cell systems for targeted delivery of nano- and microcarriers loaded with drugs or biomolecules (review) |
| title_full | Promising cell systems for targeted delivery of nano- and microcarriers loaded with drugs or biomolecules (review) |
| title_fullStr | Promising cell systems for targeted delivery of nano- and microcarriers loaded with drugs or biomolecules (review) |
| title_full_unstemmed | Promising cell systems for targeted delivery of nano- and microcarriers loaded with drugs or biomolecules (review) |
| title_short | Promising cell systems for targeted delivery of nano- and microcarriers loaded with drugs or biomolecules (review) |
| title_sort | promising cell systems for targeted delivery of nano and microcarriers loaded with drugs or biomolecules review |
| topic | targeted delivery of drugs and biomolecules cellular platforms achievements problems |
| url | https://www.pharmjournal.ru/jour/article/view/1974 |
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