The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderly
Abstract Background: Intermittent hypoxia, a consequence of sleep-disordered breathing (SDB), may contribute to an increased risk of cognitive decline. However, the association between SDB and cognition remains highly variable. Methods: Fifty-two community-dwelling healthy older adults (28 women) we...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-84305-3 |
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| author | Makoto Kawai S. M. Hadi Hosseini Casey Buck Rosy Karna Kai Ayinde Parker-Fong Pahnwat Tonya Taweesedt |
| author_facet | Makoto Kawai S. M. Hadi Hosseini Casey Buck Rosy Karna Kai Ayinde Parker-Fong Pahnwat Tonya Taweesedt |
| author_sort | Makoto Kawai |
| collection | DOAJ |
| description | Abstract Background: Intermittent hypoxia, a consequence of sleep-disordered breathing (SDB), may contribute to an increased risk of cognitive decline. However, the association between SDB and cognition remains highly variable. Methods: Fifty-two community-dwelling healthy older adults (28 women) were recruited. All participants underwent neuropsychiatric evaluations, simultaneous ambulatory polysomnography (PSG), and near-infrared spectroscopy (NIRS) recordings. We quantified the average coherence between oxy-Hb and SpO2 signals during SDB events to determine whether it could predict cognitive outcomes in healthy older adults, where higher coherence indicates reduced protection against systemic hypoxia. Results: The mean (SD) coherence of oxy-Hb and SpO2 was 0.16 (0.07). Linear regression analysis showed a significant association between mean coherence and worse Stroop Color Word Test scores (t=-0.304, p = .004). In contrast, oxy-Hb reduction alone and conventional SDB parameters did not show a significant association with cognition. Conclusion: This is the first report to demonstrate an association between a novel parameter of brain-systemic oxygenation coherence in SDB and cognition in older adults. A higher coherence rate of cortical oxy-Hb and systemic SpO2 during SDB may reflect a loss of compensatory mechanisms against systemic hypoxia and could help stratify older adults with a higher risk for cognitive decline. |
| format | Article |
| id | doaj-art-4fc669d5172c4ea69f9cf2fa5c13f30f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-4fc669d5172c4ea69f9cf2fa5c13f30f2025-01-12T12:14:59ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-024-84305-3The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderlyMakoto Kawai0S. M. Hadi Hosseini1Casey Buck2Rosy Karna3Kai Ayinde Parker-Fong4Pahnwat Tonya Taweesedt5Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford UniversityAbstract Background: Intermittent hypoxia, a consequence of sleep-disordered breathing (SDB), may contribute to an increased risk of cognitive decline. However, the association between SDB and cognition remains highly variable. Methods: Fifty-two community-dwelling healthy older adults (28 women) were recruited. All participants underwent neuropsychiatric evaluations, simultaneous ambulatory polysomnography (PSG), and near-infrared spectroscopy (NIRS) recordings. We quantified the average coherence between oxy-Hb and SpO2 signals during SDB events to determine whether it could predict cognitive outcomes in healthy older adults, where higher coherence indicates reduced protection against systemic hypoxia. Results: The mean (SD) coherence of oxy-Hb and SpO2 was 0.16 (0.07). Linear regression analysis showed a significant association between mean coherence and worse Stroop Color Word Test scores (t=-0.304, p = .004). In contrast, oxy-Hb reduction alone and conventional SDB parameters did not show a significant association with cognition. Conclusion: This is the first report to demonstrate an association between a novel parameter of brain-systemic oxygenation coherence in SDB and cognition in older adults. A higher coherence rate of cortical oxy-Hb and systemic SpO2 during SDB may reflect a loss of compensatory mechanisms against systemic hypoxia and could help stratify older adults with a higher risk for cognitive decline.https://doi.org/10.1038/s41598-024-84305-3 |
| spellingShingle | Makoto Kawai S. M. Hadi Hosseini Casey Buck Rosy Karna Kai Ayinde Parker-Fong Pahnwat Tonya Taweesedt The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderly Scientific Reports |
| title | The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderly |
| title_full | The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderly |
| title_fullStr | The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderly |
| title_full_unstemmed | The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderly |
| title_short | The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderly |
| title_sort | impact of brain systemic oxygenation coupling in sleep disordered breathing on cognitive function in elderly |
| url | https://doi.org/10.1038/s41598-024-84305-3 |
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