Inhibition of Farnesoid-x-receptor signaling during abdominal sepsis by dysbiosis exacerbates gut barrier dysfunction

Inhibition of Farnesoid-x-receptor signaling during abdominal sepsis by dysbiosis exacerbates gut barrier dysfunction

Abstract Background and aims Bacterial translocation and intestinal dysbiosis due to gut barrier dysfunction are widely recognized as major causes of the initiation and development of intra-abdominal sepsis. Systemic bacterial translocation and hepatic activation of the myeloid differentiation prima...

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Main Authors: Shuwen Qian, Zehua Su, Jiaqi Lin, Qianhao Hou, Xiaomei Wang, Yuling Li, Jieying Wang, Changchun Huang, Zetian Wang, Francisco Javier Cubero, Xiangrui Wang, Lijun Liao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
Sepsis
Gut microbiota
Myd88
FXR
FGF15
Probiotics
Online Access:https://doi.org/10.1186/s12964-025-02224-w
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