Quantum dot molecular beacons achieve sub-10 pM CRISPR-Cas detection in field-ready assays

Quantum dot molecular beacons achieve sub-10 pM CRISPR-Cas detection in field-ready assays

Abstract CRISPR-Cas systems have revolutionized molecular diagnostics through their specificity and programmability, yet their broad adoption is hindered by the reliance on expensive and complex instrumentation. Here, we present an optimized quantum dot (QD) molecular beacon (QD-MB) platform that in...

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Bibliographic Details
Main Authors: Drew P. Lysne, Michael H. Stewart, Kimihiro Susumu, Tomasz A. Leski, David A. Stenger, Igor L. Medintz, Sebastián A. Díaz, Christopher M. Green
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
CRISPR/Cas
Molecular beacons
Quantum dots
Förster resonance energy transfer
Cell-phone detection
Online Access:https://doi.org/10.1038/s41598-025-09434-9
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