A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion prevention
Achilles tendon is a motor organ that is prone to tissue adhesion during its repair process after rupture. Therefore, developing motion-responsive and anti-adhesive biomaterials is an important need for the repair of Achilles tendon rupture. Here, we report an injectable lubricative hydrogel (ILH) b...
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259000642500016X |
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| author | Shujie Cheng Jihong Yang Jianguo Song Xin Cao Bowen Zhou Lan Yang Chong Li Yi Wang |
| author_facet | Shujie Cheng Jihong Yang Jianguo Song Xin Cao Bowen Zhou Lan Yang Chong Li Yi Wang |
| author_sort | Shujie Cheng |
| collection | DOAJ |
| description | Achilles tendon is a motor organ that is prone to tissue adhesion during its repair process after rupture. Therefore, developing motion-responsive and anti-adhesive biomaterials is an important need for the repair of Achilles tendon rupture. Here, we report an injectable lubricative hydrogel (ILH) based on hydration lubrication mechanism, which is also motion-responsive based on sol-gel reversible transmission. The lubrication performance is achieved by zwitterionic polymers as we previously proved, and the sol-gel reversible transmission is enabled by dynamic disulfide bonds. Firstly, ILH was proved to be successfully prepared and lubricated as well as sol-gel reversible via FTIR characterization, rheological measurement and tribological tests. Then, in vitro cell experiments and coagulation tests demonstrated the optimal cytocompatibility and hemocompatibility of ILH. To evaluate the potential of ILH's biofunction in vivo, SD rats' Achilles tendon rupture & repair model was established. The animal experiments' results showed that ILH significantly prevented tendon adhesion and thus promote tendon healing by inhibiting TGFβ1-Smad2/3 pathway. We believe this work will open a new horizon for tendon adhesion-free repair. |
| format | Article |
| id | doaj-art-4f79e3b5f57c4b0ba47ba04c17d60be0 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
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| series | Materials Today Bio |
| spelling | doaj-art-4f79e3b5f57c4b0ba47ba04c17d60be02025-01-17T04:52:17ZengElsevierMaterials Today Bio2590-00642025-02-0130101458A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion preventionShujie Cheng0Jihong Yang1Jianguo Song2Xin Cao3Bowen Zhou4Lan Yang5Chong Li6Yi Wang7Basic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, ChinaBasic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, ChinaBasic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, ChinaBasic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, ChinaBasic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, ChinaBasic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, ChinaSchool of Clinic Medicine, Tsinghua University, Beijing, 100084, China; Corresponding author.Basic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, China; School of Clinic Medicine, Tsinghua University, Beijing, 100084, China; School of Mechanical and Energy Engineering, Beijing University of Technology, Beijing, 100124, China; Corresponding author. Basic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, China.Achilles tendon is a motor organ that is prone to tissue adhesion during its repair process after rupture. Therefore, developing motion-responsive and anti-adhesive biomaterials is an important need for the repair of Achilles tendon rupture. Here, we report an injectable lubricative hydrogel (ILH) based on hydration lubrication mechanism, which is also motion-responsive based on sol-gel reversible transmission. The lubrication performance is achieved by zwitterionic polymers as we previously proved, and the sol-gel reversible transmission is enabled by dynamic disulfide bonds. Firstly, ILH was proved to be successfully prepared and lubricated as well as sol-gel reversible via FTIR characterization, rheological measurement and tribological tests. Then, in vitro cell experiments and coagulation tests demonstrated the optimal cytocompatibility and hemocompatibility of ILH. To evaluate the potential of ILH's biofunction in vivo, SD rats' Achilles tendon rupture & repair model was established. The animal experiments' results showed that ILH significantly prevented tendon adhesion and thus promote tendon healing by inhibiting TGFβ1-Smad2/3 pathway. We believe this work will open a new horizon for tendon adhesion-free repair.http://www.sciencedirect.com/science/article/pii/S259000642500016XInjectable hydrogelLubricationMotion-responsiveAchilles tendonTissue adhesion |
| spellingShingle | Shujie Cheng Jihong Yang Jianguo Song Xin Cao Bowen Zhou Lan Yang Chong Li Yi Wang A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion prevention Materials Today Bio Injectable hydrogel Lubrication Motion-responsive Achilles tendon Tissue adhesion |
| title | A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion prevention |
| title_full | A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion prevention |
| title_fullStr | A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion prevention |
| title_full_unstemmed | A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion prevention |
| title_short | A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion prevention |
| title_sort | motion responsive injectable lubricative hydrogel for efficient achilles tendon adhesion prevention |
| topic | Injectable hydrogel Lubrication Motion-responsive Achilles tendon Tissue adhesion |
| url | http://www.sciencedirect.com/science/article/pii/S259000642500016X |
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