Melatonin exchange in infertile women with repeated implantation failures
Background. Repeated implantation failure occurs in approximately 10–15% of women undergoing in vitro fertilization and embryo transfer (IVF-ET) cycles. One of the important factors is the changed morpho-functional state of the endometrium and chronodestruction in the woman’s body. Objective of t...
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Publishing House TRILIST
2024-03-01
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| Series: | Репродуктивная эндокринология |
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| Online Access: | https://reproduct-endo.com/article/view/301917 |
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| author | O.M. Nosenko R.Y. Demydchyk |
| author_facet | O.M. Nosenko R.Y. Demydchyk |
| author_sort | O.M. Nosenko |
| collection | DOAJ |
| description | Background. Repeated implantation failure occurs in approximately 10–15% of women undergoing in vitro fertilization and embryo transfer (IVF-ET) cycles. One of the important factors is the changed morpho-functional state of the endometrium and chronodestruction in the woman’s body.
Objective of the study: to determine the characteristics of melatonin (MT) metabolism in infertile women with repeated implantation failures in IVF-ET cycles.
Material and methods. 103 women of reproductive age with infertility and repeated implantation failures who were treated in IVF-ET cycles were observed. Depending on the onset of pregnancy in the current IVF-ET cycle, women were divided into 2 groups: group A – 35 women with the onset of pregnancy, group B – 68 patients without the onset of pregnancy. The control group (group C) included 32 healthy fertile women. The MT level in blood serum and 6-sulfatoxymelatonin (aMT6s) in urine was determined.
Results. The initial levels of MT in patients of group A (11.38 ± 0.38 pg/ml) and in group B (9.55 ± 0.27 pg/ml) were lower than in group C (13.67 ± 0.65 pg/ml) in 1.20 (p < 0.01) and 1.43 (p < 0.01) times, respectively. At the same time, the level of MT in women of group A was 1.19 times higher than in the group B (p < 0.03). Excretion of aMT6s in urine in group A (5.09 ± 0.19 ng/ml Cr) and in group B (3.03 ± 0.09 ng/ml Cr) were lower than in group C (6.12 ± 0.21 ng/ml Cr) respectively in 1.20 (p < 0.01) and 2.02 (p < 0.01) times. The aMT6s concentration in urine in patients of group A was 1.68 times higher than in group B (p < 0.01). A direct relationship was established between the levels of serum MT and urinary aMT6s, which was most adequately approximated by a polynomial dependence: y = 0.0139x2 – 0.1127x + 3.2978, R² = 0.2994, r = 0.51, p < 0.01.
Conclusions. Women with repeated implantation failures are characterized by a decrease in the level of MT in blood serum and its main metabolite aMT6s in urine, which may be one of the key factors of implantation failure. |
| format | Article |
| id | doaj-art-4f79b94543a54b43a8b9958389a5759f |
| institution | Kabale University |
| issn | 2309-4117 2411-1295 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Publishing House TRILIST |
| record_format | Article |
| series | Репродуктивная эндокринология |
| spelling | doaj-art-4f79b94543a54b43a8b9958389a5759f2024-12-07T01:10:43ZengPublishing House TRILISTРепродуктивная эндокринология2309-41172411-12952024-03-01719410210.18370/2309-4117.2024.71.94-102340282Melatonin exchange in infertile women with repeated implantation failuresO.M. Nosenko0https://orcid.org/0000-0002-7089-2476R.Y. Demydchyk1https://orcid.org/0009-0004-2385-8664Odesa National Medical University, Odesa, UkraineOdesa National Medical University, Odesa, UkraineBackground. Repeated implantation failure occurs in approximately 10–15% of women undergoing in vitro fertilization and embryo transfer (IVF-ET) cycles. One of the important factors is the changed morpho-functional state of the endometrium and chronodestruction in the woman’s body. Objective of the study: to determine the characteristics of melatonin (MT) metabolism in infertile women with repeated implantation failures in IVF-ET cycles. Material and methods. 103 women of reproductive age with infertility and repeated implantation failures who were treated in IVF-ET cycles were observed. Depending on the onset of pregnancy in the current IVF-ET cycle, women were divided into 2 groups: group A – 35 women with the onset of pregnancy, group B – 68 patients without the onset of pregnancy. The control group (group C) included 32 healthy fertile women. The MT level in blood serum and 6-sulfatoxymelatonin (aMT6s) in urine was determined. Results. The initial levels of MT in patients of group A (11.38 ± 0.38 pg/ml) and in group B (9.55 ± 0.27 pg/ml) were lower than in group C (13.67 ± 0.65 pg/ml) in 1.20 (p < 0.01) and 1.43 (p < 0.01) times, respectively. At the same time, the level of MT in women of group A was 1.19 times higher than in the group B (p < 0.03). Excretion of aMT6s in urine in group A (5.09 ± 0.19 ng/ml Cr) and in group B (3.03 ± 0.09 ng/ml Cr) were lower than in group C (6.12 ± 0.21 ng/ml Cr) respectively in 1.20 (p < 0.01) and 2.02 (p < 0.01) times. The aMT6s concentration in urine in patients of group A was 1.68 times higher than in group B (p < 0.01). A direct relationship was established between the levels of serum MT and urinary aMT6s, which was most adequately approximated by a polynomial dependence: y = 0.0139x2 – 0.1127x + 3.2978, R² = 0.2994, r = 0.51, p < 0.01. Conclusions. Women with repeated implantation failures are characterized by a decrease in the level of MT in blood serum and its main metabolite aMT6s in urine, which may be one of the key factors of implantation failure.https://reproduct-endo.com/article/view/301917infertilityrepeated implantation failureendometriummelatonin6-sulfatoxymelatonin |
| spellingShingle | O.M. Nosenko R.Y. Demydchyk Melatonin exchange in infertile women with repeated implantation failures Репродуктивная эндокринология infertility repeated implantation failure endometrium melatonin 6-sulfatoxymelatonin |
| title | Melatonin exchange in infertile women with repeated implantation failures |
| title_full | Melatonin exchange in infertile women with repeated implantation failures |
| title_fullStr | Melatonin exchange in infertile women with repeated implantation failures |
| title_full_unstemmed | Melatonin exchange in infertile women with repeated implantation failures |
| title_short | Melatonin exchange in infertile women with repeated implantation failures |
| title_sort | melatonin exchange in infertile women with repeated implantation failures |
| topic | infertility repeated implantation failure endometrium melatonin 6-sulfatoxymelatonin |
| url | https://reproduct-endo.com/article/view/301917 |
| work_keys_str_mv | AT omnosenko melatoninexchangeininfertilewomenwithrepeatedimplantationfailures AT rydemydchyk melatoninexchangeininfertilewomenwithrepeatedimplantationfailures |