Sleep disturbance and hypertension mediated by systemic inflammatory response index in NHANES
Abstract Both hypertension and sleep disturbance have been closely linked to inflammation. However, the specific role of inflammation in the relationship between sleep disturbance and hypertension remains unclear. We investigated the pairwise associations among a novel inflammatory marker (systemic...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-09529-3 |
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| author | Zhaoxing Cao Fangfang Zhuo Fei Yan Xi Hu Guiling Xia Cheng Huang Ting Lu Zhipeng Pu Runze Huang Zhangrong Chen |
| author_facet | Zhaoxing Cao Fangfang Zhuo Fei Yan Xi Hu Guiling Xia Cheng Huang Ting Lu Zhipeng Pu Runze Huang Zhangrong Chen |
| author_sort | Zhaoxing Cao |
| collection | DOAJ |
| description | Abstract Both hypertension and sleep disturbance have been closely linked to inflammation. However, the specific role of inflammation in the relationship between sleep disturbance and hypertension remains unclear. We investigated the pairwise associations among a novel inflammatory marker (systemic immune inflammation index ), sleep disturbance, and hypertension in a powerful, racially diverse sample (n = 23,414) from the 2005–2020 National Health and Nutrition Examination Survey (NHANES). We found that participants with high blood pressure and/or sleep disorders had higher levels of Systemic Immune-Inflammatory Index (SII) than those without hypertension or sleep disorders.SII slightly but significantly mediated the relationship between sleep disturbance and hypertension in males but not in females, after adjusting for all covariates (proportion mediate [PM], 1.36%; total effect [TE], 0.0931; direct effect [ADE], 0.0917; verage causal mediation effects [ACME] = 0.0013 [95% CI = 0.0004–0.0024], p = 0.002, in males. Our research showed that SII, sleep disturbance, and hypertension are related. Increased SII levels slightly mediated the association between sleep disturbance and hypertension. |
| format | Article |
| id | doaj-art-4f63c37a6c934e7baf9f0376229b024f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-4f63c37a6c934e7baf9f0376229b024f2025-08-20T03:46:01ZengNature PortfolioScientific Reports2045-23222025-07-011511910.1038/s41598-025-09529-3Sleep disturbance and hypertension mediated by systemic inflammatory response index in NHANESZhaoxing Cao0Fangfang Zhuo1Fei Yan2Xi Hu3Guiling Xia4Cheng Huang5Ting Lu6Zhipeng Pu7Runze Huang8Zhangrong Chen9Department of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica UniversityDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica UniversityDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica UniversityDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica UniversityDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica UniversityDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica UniversityDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica UniversityDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica UniversityDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica UniversityDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica UniversityAbstract Both hypertension and sleep disturbance have been closely linked to inflammation. However, the specific role of inflammation in the relationship between sleep disturbance and hypertension remains unclear. We investigated the pairwise associations among a novel inflammatory marker (systemic immune inflammation index ), sleep disturbance, and hypertension in a powerful, racially diverse sample (n = 23,414) from the 2005–2020 National Health and Nutrition Examination Survey (NHANES). We found that participants with high blood pressure and/or sleep disorders had higher levels of Systemic Immune-Inflammatory Index (SII) than those without hypertension or sleep disorders.SII slightly but significantly mediated the relationship between sleep disturbance and hypertension in males but not in females, after adjusting for all covariates (proportion mediate [PM], 1.36%; total effect [TE], 0.0931; direct effect [ADE], 0.0917; verage causal mediation effects [ACME] = 0.0013 [95% CI = 0.0004–0.0024], p = 0.002, in males. Our research showed that SII, sleep disturbance, and hypertension are related. Increased SII levels slightly mediated the association between sleep disturbance and hypertension.https://doi.org/10.1038/s41598-025-09529-3SleepInflammationHypertensionSIIMediation |
| spellingShingle | Zhaoxing Cao Fangfang Zhuo Fei Yan Xi Hu Guiling Xia Cheng Huang Ting Lu Zhipeng Pu Runze Huang Zhangrong Chen Sleep disturbance and hypertension mediated by systemic inflammatory response index in NHANES Scientific Reports Sleep Inflammation Hypertension SII Mediation |
| title | Sleep disturbance and hypertension mediated by systemic inflammatory response index in NHANES |
| title_full | Sleep disturbance and hypertension mediated by systemic inflammatory response index in NHANES |
| title_fullStr | Sleep disturbance and hypertension mediated by systemic inflammatory response index in NHANES |
| title_full_unstemmed | Sleep disturbance and hypertension mediated by systemic inflammatory response index in NHANES |
| title_short | Sleep disturbance and hypertension mediated by systemic inflammatory response index in NHANES |
| title_sort | sleep disturbance and hypertension mediated by systemic inflammatory response index in nhanes |
| topic | Sleep Inflammation Hypertension SII Mediation |
| url | https://doi.org/10.1038/s41598-025-09529-3 |
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