A study on the variability and correlation of ocular biological measurement parameters in adult myopic patients
ObjectiveThis study aims to explore the differences in ocular parameters among adult myopic patients with different degrees of myopia and axial lengths, and to investigate the correlations between these ocular parameters.MethodsThis single-center observational study collected clinical data from myop...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1526703/full |
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| author | Fangxing Zhou Nan Chen Hui Qian Di Gong Kunke Li |
| author_facet | Fangxing Zhou Nan Chen Hui Qian Di Gong Kunke Li |
| author_sort | Fangxing Zhou |
| collection | DOAJ |
| description | ObjectiveThis study aims to explore the differences in ocular parameters among adult myopic patients with different degrees of myopia and axial lengths, and to investigate the correlations between these ocular parameters.MethodsThis single-center observational study collected clinical data from myopic patients aged 18–45 years who visited the Eye Hospital of Nanjing Medical University between January and June 2023. The data included laterality, diopter of spherical power (DS), diopter of cylindrical power (DC), spherical equivalent (SE), axial length (AL), central corneal thickness (CCT), flat meridian keratometry (K1), steep meridian keratometry (K2), mean keratometry (Km), anterior chamber depth (ACD), corneal radius of curvature (CRC), and axial length/corneal radius of curvature ratio (AL/CRC). Following predefined inclusion and exclusion criteria, 1,026 eyes were included in the study. Patients were grouped based on SE and AL parameters into different degrees of myopia. Analysis of variance (ANOVA) and Welch ANOVA were used to compare intergroup differences. Spearman correlation coefficients were calculated to analyze the correlations between parameters, and linear regression and ROC curve analyses were performed.ResultsSignificant differences (p < 0.05) were found among mild, moderate, and high myopia groups in parameters such as DS, DC, AL, K1, Km, ACD, CRC, and AL/CRC. Significant differences (p < 0.05) were also found in DS, DC, SE, CCT, K1, K2, Km, ACD, CRC, and AL/CRC among different axial length groups. Spearman correlation analysis showed a strong correlation between AL and DS, SE, and between AL/CRC and DS, SE, AL. Linear regression analysis revealed that the coefficient of determination (R2) for AL and SE was 0.699, and for AL/CRC and SE, it was 0.861. ROC curve analysis demonstrated high accuracy for both AL and AL/CRC in identifying high myopia, with an AUC of 0.952 for AL/CRC, which was superior to the AUC of 0.905 for AL (p < 0.05).ConclusionThis study found significant differences in ocular parameters among patients with different degrees of myopia and axial lengths. There was a significant negative correlation between AL, AL/CRC, and SE. Compared to AL, AL/CRC had a stronger correlation with SE and higher accuracy in identifying high myopia. |
| format | Article |
| id | doaj-art-4f5c0b1dcfdb4304a02ef3f5257fa1dd |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-4f5c0b1dcfdb4304a02ef3f5257fa1dd2025-01-07T05:24:08ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15267031526703A study on the variability and correlation of ocular biological measurement parameters in adult myopic patientsFangxing Zhou0Nan Chen1Hui Qian2Di Gong3Kunke Li4Fuzhou Aier Eye Hospital, Fuzhou, Jiangxi, ChinaEye Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaEye Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, Guangdong, ChinaShenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, Guangdong, ChinaObjectiveThis study aims to explore the differences in ocular parameters among adult myopic patients with different degrees of myopia and axial lengths, and to investigate the correlations between these ocular parameters.MethodsThis single-center observational study collected clinical data from myopic patients aged 18–45 years who visited the Eye Hospital of Nanjing Medical University between January and June 2023. The data included laterality, diopter of spherical power (DS), diopter of cylindrical power (DC), spherical equivalent (SE), axial length (AL), central corneal thickness (CCT), flat meridian keratometry (K1), steep meridian keratometry (K2), mean keratometry (Km), anterior chamber depth (ACD), corneal radius of curvature (CRC), and axial length/corneal radius of curvature ratio (AL/CRC). Following predefined inclusion and exclusion criteria, 1,026 eyes were included in the study. Patients were grouped based on SE and AL parameters into different degrees of myopia. Analysis of variance (ANOVA) and Welch ANOVA were used to compare intergroup differences. Spearman correlation coefficients were calculated to analyze the correlations between parameters, and linear regression and ROC curve analyses were performed.ResultsSignificant differences (p < 0.05) were found among mild, moderate, and high myopia groups in parameters such as DS, DC, AL, K1, Km, ACD, CRC, and AL/CRC. Significant differences (p < 0.05) were also found in DS, DC, SE, CCT, K1, K2, Km, ACD, CRC, and AL/CRC among different axial length groups. Spearman correlation analysis showed a strong correlation between AL and DS, SE, and between AL/CRC and DS, SE, AL. Linear regression analysis revealed that the coefficient of determination (R2) for AL and SE was 0.699, and for AL/CRC and SE, it was 0.861. ROC curve analysis demonstrated high accuracy for both AL and AL/CRC in identifying high myopia, with an AUC of 0.952 for AL/CRC, which was superior to the AUC of 0.905 for AL (p < 0.05).ConclusionThis study found significant differences in ocular parameters among patients with different degrees of myopia and axial lengths. There was a significant negative correlation between AL, AL/CRC, and SE. Compared to AL, AL/CRC had a stronger correlation with SE and higher accuracy in identifying high myopia.https://www.frontiersin.org/articles/10.3389/fmed.2024.1526703/fullmyopiaaxial lengthspherical equivalentcorneal radius of curvatureaxial length/corneal radius of curvature ratio |
| spellingShingle | Fangxing Zhou Nan Chen Hui Qian Di Gong Kunke Li A study on the variability and correlation of ocular biological measurement parameters in adult myopic patients Frontiers in Medicine myopia axial length spherical equivalent corneal radius of curvature axial length/corneal radius of curvature ratio |
| title | A study on the variability and correlation of ocular biological measurement parameters in adult myopic patients |
| title_full | A study on the variability and correlation of ocular biological measurement parameters in adult myopic patients |
| title_fullStr | A study on the variability and correlation of ocular biological measurement parameters in adult myopic patients |
| title_full_unstemmed | A study on the variability and correlation of ocular biological measurement parameters in adult myopic patients |
| title_short | A study on the variability and correlation of ocular biological measurement parameters in adult myopic patients |
| title_sort | study on the variability and correlation of ocular biological measurement parameters in adult myopic patients |
| topic | myopia axial length spherical equivalent corneal radius of curvature axial length/corneal radius of curvature ratio |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1526703/full |
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