STING signaling contributes to methotrexate-induced liver injury by regulating ferroptosis in mice

STING signaling contributes to methotrexate-induced liver injury by regulating ferroptosis in mice

Methotrexate (MTX), an anti-metabolite agent, is a widely used chemotherapeutic anticancer drug, but its hepatotoxicity severely limits its clinical application. Nevertheless, the precise mechanisms of MTX-caused liver damage are extremely intricate and still need to be fully clarified. In the curre...

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Main Authors: Hong-fei Wang, Yu-qiong He, Zong Ke, Zhi-wei Liang, jia-hao Zhou, Ke Ni, Yu Zhang, Ren-feng Li, Jian-feng Xue, Can-can Zhou, Jia-Shuang Xu
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Methotrexate
Liver
STING
Ferroptosis
ER stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324013824
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