Association between ZJU index and gallstones in US adult: a cross-sectional study of NHANES 2017–2020
Abstract Background Based on triglyceride, body mass index (BMI), alanine aminotransferase/ aspartate aminotransferase ratio, fasting blood glucose, the ZJU index is proven to be a novel and effective parameter for screening NAFLD in Chinese. This study aims to evaluate the correlation between ZJU v...
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BMC
2024-12-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-024-03553-9 |
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| author | Zuopu Xie Xianpei Chen Chunming Xie Qi Yang Hao Lin |
| author_facet | Zuopu Xie Xianpei Chen Chunming Xie Qi Yang Hao Lin |
| author_sort | Zuopu Xie |
| collection | DOAJ |
| description | Abstract Background Based on triglyceride, body mass index (BMI), alanine aminotransferase/ aspartate aminotransferase ratio, fasting blood glucose, the ZJU index is proven to be a novel and effective parameter for screening NAFLD in Chinese. This study aims to evaluate the correlation between ZJU values and the risk of developing gallstones. Methods The data from the National Health and Nutrition Examination Survey (NHANES) database during the period from 2017 to 2020 were analyzed in this cross-sectional study. And 6155 participants were included to assess the correlation between the ZJU index and the formation of gallstones through multivariate logistic regression, receiver operating characteristic (ROC) curve, subgroup analysis, and restricted cubic spline regression (RCS) analyses. Results In this population-based study, 6155 participants aged 18 years and older were included, among which, 671 had gallstones. Logistic regression and RCS regression analyses indicated a significant positive non-linearly correlation between the ZJU index and the prevalence of gallstones (OR = 1.044, 95% CI: 1.032, 1.056), with an inflection point of 40.6. Subgroup analysis further revealed a stronger correlation between the risk of developing gallstones and the ZJU index in females. ROC analysis indicated that the ZJU index (AUC = 0.653) can serve as a more robust predictor for developing gallstones compared to traditional indices, with a sensitivity of 55.9%, a specificity of 67.1% and a cutoff of 43.4. Conclusion This study provides evidence that elevated the ZJU index is correlated with an increased risk of developing gallstones. |
| format | Article |
| id | doaj-art-4f1c8b203b7847f1afe1ddc439613bb0 |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-4f1c8b203b7847f1afe1ddc439613bb02024-12-22T12:29:14ZengBMCBMC Gastroenterology1471-230X2024-12-0124111010.1186/s12876-024-03553-9Association between ZJU index and gallstones in US adult: a cross-sectional study of NHANES 2017–2020Zuopu Xie0Xianpei Chen1Chunming Xie2Qi Yang3Hao Lin4Department of Gastroenterology, Pingyang Hospital of Wenzhou Medical UniversityDepartment of Gastroenterology, Pingyang Hospital of Wenzhou Medical UniversityDigestive Endoscopy Center, Pingyang Hospital of Wenzhou Medical UniversityDepartment of Gastroenterology, Pingyang Hospital of Wenzhou Medical UniversityDepartment of Gastroenterology, Pingyang Hospital of Wenzhou Medical UniversityAbstract Background Based on triglyceride, body mass index (BMI), alanine aminotransferase/ aspartate aminotransferase ratio, fasting blood glucose, the ZJU index is proven to be a novel and effective parameter for screening NAFLD in Chinese. This study aims to evaluate the correlation between ZJU values and the risk of developing gallstones. Methods The data from the National Health and Nutrition Examination Survey (NHANES) database during the period from 2017 to 2020 were analyzed in this cross-sectional study. And 6155 participants were included to assess the correlation between the ZJU index and the formation of gallstones through multivariate logistic regression, receiver operating characteristic (ROC) curve, subgroup analysis, and restricted cubic spline regression (RCS) analyses. Results In this population-based study, 6155 participants aged 18 years and older were included, among which, 671 had gallstones. Logistic regression and RCS regression analyses indicated a significant positive non-linearly correlation between the ZJU index and the prevalence of gallstones (OR = 1.044, 95% CI: 1.032, 1.056), with an inflection point of 40.6. Subgroup analysis further revealed a stronger correlation between the risk of developing gallstones and the ZJU index in females. ROC analysis indicated that the ZJU index (AUC = 0.653) can serve as a more robust predictor for developing gallstones compared to traditional indices, with a sensitivity of 55.9%, a specificity of 67.1% and a cutoff of 43.4. Conclusion This study provides evidence that elevated the ZJU index is correlated with an increased risk of developing gallstones.https://doi.org/10.1186/s12876-024-03553-9Insulin resistanceObesityZJU indexGallstonesBody mass index |
| spellingShingle | Zuopu Xie Xianpei Chen Chunming Xie Qi Yang Hao Lin Association between ZJU index and gallstones in US adult: a cross-sectional study of NHANES 2017–2020 BMC Gastroenterology Insulin resistance Obesity ZJU index Gallstones Body mass index |
| title | Association between ZJU index and gallstones in US adult: a cross-sectional study of NHANES 2017–2020 |
| title_full | Association between ZJU index and gallstones in US adult: a cross-sectional study of NHANES 2017–2020 |
| title_fullStr | Association between ZJU index and gallstones in US adult: a cross-sectional study of NHANES 2017–2020 |
| title_full_unstemmed | Association between ZJU index and gallstones in US adult: a cross-sectional study of NHANES 2017–2020 |
| title_short | Association between ZJU index and gallstones in US adult: a cross-sectional study of NHANES 2017–2020 |
| title_sort | association between zju index and gallstones in us adult a cross sectional study of nhanes 2017 2020 |
| topic | Insulin resistance Obesity ZJU index Gallstones Body mass index |
| url | https://doi.org/10.1186/s12876-024-03553-9 |
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