Long-term Outcomes (10 years) of Hepatic Transplantation in a Patient with Hepatic Adenomatosis: A Case Report
Hepatocellular adenoma is a rare benign liver neoplasm, and hepatic adenomatosis is associated with risks such as intertumoral hemorrhage or necrosis. The imaging features of adenomatosis closely resemble those of solitary adenomas, differing only in the number of lesions. This study reports a case...
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_754_24 |
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| author | Abdullah Almunifi |
| author_facet | Abdullah Almunifi |
| author_sort | Abdullah Almunifi |
| collection | DOAJ |
| description | Hepatocellular adenoma is a rare benign liver neoplasm, and hepatic adenomatosis is associated with risks such as intertumoral hemorrhage or necrosis. The imaging features of adenomatosis closely resemble those of solitary adenomas, differing only in the number of lesions. This study reports a case of an 18-year-old woman with perturbed liver function enzymes and multiple hepatic nodules. She had no significant medical history, chronic liver disease, or diabetes and was not taking any regular medications or anabolic steroids. Abdominal ultrasound revealed hepatomegaly and multiple hepatic nodules. Subsequently, the patient underwent hepatic orthotropic transplantation without any complications and was followed-up for 10 years. Multiple lesions with suspicious or confirmed malignant transformation and unwillingness to undergo surgical resection are considered leading indications for hepatic transplantation. Despite efforts to manage the condition conservatively, including hepatic transplantation, the patient experienced complications related to immunosuppressant therapy and ultimately developed chronic rejection. Hepatic transplantation is rarely indicated for benign liver tumors, especially when life-threatening complications or hepatic tumor malignant transformation cannot be ruled out, and tumors are unrespectable. This case highlights the complexity of managing hepatic adenomatosis and underscores the importance of individualized treatment strategies and long-term follow-up. |
| format | Article |
| id | doaj-art-4f160f73af67465496b711a7b56ac739 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-4f160f73af67465496b711a7b56ac7392025-01-14T05:29:55ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S4126S412910.4103/jpbs.jpbs_754_24Long-term Outcomes (10 years) of Hepatic Transplantation in a Patient with Hepatic Adenomatosis: A Case ReportAbdullah AlmunifiHepatocellular adenoma is a rare benign liver neoplasm, and hepatic adenomatosis is associated with risks such as intertumoral hemorrhage or necrosis. The imaging features of adenomatosis closely resemble those of solitary adenomas, differing only in the number of lesions. This study reports a case of an 18-year-old woman with perturbed liver function enzymes and multiple hepatic nodules. She had no significant medical history, chronic liver disease, or diabetes and was not taking any regular medications or anabolic steroids. Abdominal ultrasound revealed hepatomegaly and multiple hepatic nodules. Subsequently, the patient underwent hepatic orthotropic transplantation without any complications and was followed-up for 10 years. Multiple lesions with suspicious or confirmed malignant transformation and unwillingness to undergo surgical resection are considered leading indications for hepatic transplantation. Despite efforts to manage the condition conservatively, including hepatic transplantation, the patient experienced complications related to immunosuppressant therapy and ultimately developed chronic rejection. Hepatic transplantation is rarely indicated for benign liver tumors, especially when life-threatening complications or hepatic tumor malignant transformation cannot be ruled out, and tumors are unrespectable. This case highlights the complexity of managing hepatic adenomatosis and underscores the importance of individualized treatment strategies and long-term follow-up.https://journals.lww.com/10.4103/jpbs.jpbs_754_24adenomacase reporthepatic adenomatoseshepatic transplantationhepatocellular adenomaliverliver transplantation |
| spellingShingle | Abdullah Almunifi Long-term Outcomes (10 years) of Hepatic Transplantation in a Patient with Hepatic Adenomatosis: A Case Report Journal of Pharmacy and Bioallied Sciences adenoma case report hepatic adenomatoses hepatic transplantation hepatocellular adenoma liver liver transplantation |
| title | Long-term Outcomes (10 years) of Hepatic Transplantation in a Patient with Hepatic Adenomatosis: A Case Report |
| title_full | Long-term Outcomes (10 years) of Hepatic Transplantation in a Patient with Hepatic Adenomatosis: A Case Report |
| title_fullStr | Long-term Outcomes (10 years) of Hepatic Transplantation in a Patient with Hepatic Adenomatosis: A Case Report |
| title_full_unstemmed | Long-term Outcomes (10 years) of Hepatic Transplantation in a Patient with Hepatic Adenomatosis: A Case Report |
| title_short | Long-term Outcomes (10 years) of Hepatic Transplantation in a Patient with Hepatic Adenomatosis: A Case Report |
| title_sort | long term outcomes 10 years of hepatic transplantation in a patient with hepatic adenomatosis a case report |
| topic | adenoma case report hepatic adenomatoses hepatic transplantation hepatocellular adenoma liver liver transplantation |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_754_24 |
| work_keys_str_mv | AT abdullahalmunifi longtermoutcomes10yearsofhepatictransplantationinapatientwithhepaticadenomatosisacasereport |