A proof-of-concept study in small and large animal models for coupling liver normothermic machine perfusion with mesenchymal stromal cell bioreactors

A proof-of-concept study in small and large animal models for coupling liver normothermic machine perfusion with mesenchymal stromal cell bioreactors

Abstract To fully harness mesenchymal-stromal-cells (MSCs)’ benefits during Normothermic Machine Perfusion (NMP), we developed an advanced NMP platform coupled with a MSC-bioreactor and investigated its bio-molecular effects and clinical feasibility using rat and porcine models. The study involved t...

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Main Authors: Umberto Cillo, Caterina Lonati, Alessandra Bertacco, Lucrezia Magnini, Michele Battistin, Liver NMP Consortium, Lara Borsetto, Francesco Dazzi, David Al-Adra, Enrico Gringeri, Maria Laura Bacci, Andrea Schlegel, Daniele Dondossola
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55217-7
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