Elevated C-Reactive Protein: Low Quality Sleep as an Inflammation Indicator
Background: High inflammation levels and obesity are each linked to worse health outcomes. Low-quality sleep is linked to higher inflammation. Method: This cross-sectional study investigated whether: individuals with low-quality sleep have higher inflammation; regardless of BMI; low-quality sleep...
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| Format: | Article |
| Language: | English |
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Adventist University of Africa
2022-07-01
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| Series: | Pan-African Journal of Health and Environmental Science |
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| Online Access: | https://journals.aua.ke/ajhes/article/view/114 |
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| author | Katie Viehmann-Wical Jerry W. Lee Seth Wiafe Matheni Sathananthan Anna Nelson |
| author_facet | Katie Viehmann-Wical Jerry W. Lee Seth Wiafe Matheni Sathananthan Anna Nelson |
| author_sort | Katie Viehmann-Wical |
| collection | DOAJ |
| description | Background: High inflammation levels and obesity are each linked to worse health outcomes. Low-quality sleep is linked to higher inflammation.
Method: This cross-sectional study investigated whether: individuals with low-quality sleep have higher inflammation; regardless of BMI; low-quality sleep interacts with BMI regarding cross-sectional prediction of inflammation; and whether sleep quality questions could identify this association. We utilized linear regression with 500 African American and Caucasian adults from an Adventist Health Study-2 subset, who completed additional biological indicator testing.
Results: Higher total sleep disturbance (TSD) was associated with increased C-reactive Protein (CRP), p= 0.008, (95% CI = 0.22 to 1.42). The interaction of TSD and BMI was significant in a curvilinear association, p = 0.018,(95% CI = -0.05 to -0.01). As TSD increased, CRP increased; however, the association existed primarily in obese individuals (BMI >30). Low-quality sleep is associated with increased CRP levels, which is a consistent inflammation indicator.
Conclusion: Obesity was not a risk factor for significantly increased CRP until sleep disturbance was indicated as “often” or “almost every day”. This study supports asking sleep quality questions in primary care, for early identification of risk. |
| format | Article |
| id | doaj-art-4f038c39eabd44b9bdc3d57be17c2618 |
| institution | Kabale University |
| issn | 2789-6196 2789-620X |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Adventist University of Africa |
| record_format | Article |
| series | Pan-African Journal of Health and Environmental Science |
| spelling | doaj-art-4f038c39eabd44b9bdc3d57be17c26182024-11-11T19:39:18ZengAdventist University of AfricaPan-African Journal of Health and Environmental Science2789-61962789-620X2022-07-011175Elevated C-Reactive Protein: Low Quality Sleep as an Inflammation IndicatorKatie Viehmann-Wical0https://orcid.org/0000-0001-6238-3746Jerry W. Lee1Seth Wiafe2https://orcid.org/0000-0001-6085-9405Matheni Sathananthan3https://orcid.org/0000-0002-8502-1032Anna Nelson4https://orcid.org/0000-0003-0683-8122School of Public Health, Loma Linda University, USASchool of Public Health, Loma Linda University, USASchool of Public Health, Loma Linda University, USASchool of Medicine, Loma Linda University, USASchool of Public Health, Loma Linda University, USABackground: High inflammation levels and obesity are each linked to worse health outcomes. Low-quality sleep is linked to higher inflammation. Method: This cross-sectional study investigated whether: individuals with low-quality sleep have higher inflammation; regardless of BMI; low-quality sleep interacts with BMI regarding cross-sectional prediction of inflammation; and whether sleep quality questions could identify this association. We utilized linear regression with 500 African American and Caucasian adults from an Adventist Health Study-2 subset, who completed additional biological indicator testing. Results: Higher total sleep disturbance (TSD) was associated with increased C-reactive Protein (CRP), p= 0.008, (95% CI = 0.22 to 1.42). The interaction of TSD and BMI was significant in a curvilinear association, p = 0.018,(95% CI = -0.05 to -0.01). As TSD increased, CRP increased; however, the association existed primarily in obese individuals (BMI >30). Low-quality sleep is associated with increased CRP levels, which is a consistent inflammation indicator. Conclusion: Obesity was not a risk factor for significantly increased CRP until sleep disturbance was indicated as “often” or “almost every day”. This study supports asking sleep quality questions in primary care, for early identification of risk.https://journals.aua.ke/ajhes/article/view/114inflammationcross-sectionalsleep disturbancebody mass indexsleep questionsprimary careunited statesc-reactive proteinobesitysleep quality |
| spellingShingle | Katie Viehmann-Wical Jerry W. Lee Seth Wiafe Matheni Sathananthan Anna Nelson Elevated C-Reactive Protein: Low Quality Sleep as an Inflammation Indicator Pan-African Journal of Health and Environmental Science inflammation cross-sectional sleep disturbance body mass index sleep questions primary care united states c-reactive protein obesity sleep quality |
| title | Elevated C-Reactive Protein: Low Quality Sleep as an Inflammation Indicator |
| title_full | Elevated C-Reactive Protein: Low Quality Sleep as an Inflammation Indicator |
| title_fullStr | Elevated C-Reactive Protein: Low Quality Sleep as an Inflammation Indicator |
| title_full_unstemmed | Elevated C-Reactive Protein: Low Quality Sleep as an Inflammation Indicator |
| title_short | Elevated C-Reactive Protein: Low Quality Sleep as an Inflammation Indicator |
| title_sort | elevated c reactive protein low quality sleep as an inflammation indicator |
| topic | inflammation cross-sectional sleep disturbance body mass index sleep questions primary care united states c-reactive protein obesity sleep quality |
| url | https://journals.aua.ke/ajhes/article/view/114 |
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