Targeting the LMP1‐ALIX axis in EBV+ nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti‐tumor immunity

Targeting the LMP1‐ALIX axis in EBV+ nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti‐tumor immunity

Abstract Background Immunotherapy has revolutionized the therapeutical regimen for nasopharyngeal carcinoma (NPC), yet its response rate remains insufficient. Programmed death‐ligand 1 (PD‐L1) on small extracellular vesicles (sEVs) mediates local and peripheral immunosuppression in tumors, and the m...

Full description

Saved in:

Bibliographic Details
Main Authors:	Fajian He, Yan Gong, Gan Tao, Jianguo Zhang, Qiuji Wu, Yushuang Tan, Yajie Cheng, Chunsheng Wang, Jinru Yang, Linzhi Han, Zhihao Wang, Yanping Gao, Jingyi He, Rui Bai, Peikai Sun, Xiaoyan Yu, Yajuan Zhou, Conghua Xie
Format:	Article
Language:	English
Published:	Wiley 2024-12-01
Series:	Cancer Communications
Subjects:	Epstein‐Barr virus latent membrane protein 1 small extracellular vesicle PD‐L1 ALIX nasopharyngeal carcinoma
Online Access:	https://doi.org/10.1002/cac2.12619
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Specific Immune Responses and Oncolytic Effects Induced by EBV LMP2A-Armed Modified Ankara-Vaccinia Virus Vectored Vaccines in Nasopharyngeal Cancer
by: Liying Sun, et al.
Published: (2025-01-01)

Smoking can increase nasopharyngeal carcinoma risk by repeatedly reactivating Epstein‐Barr Virus: An analysis of a prospective study in southern China
by: Ting Hu, et al.
Published: (2019-05-01)

Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential
by: Madhan Krishnan, et al.
Published: (2024-09-01)

First Indonesian Nasopharyngeal Cancer Whole Epigenome Sequencing Identify Tumour Suppressor CpG Methylation
by: Handoko, et al.
Published: (2025-01-01)

A Canadian Perspective on Systemic Therapy for Recurrent or Metastatic Nasopharyngeal Carcinoma
by: Anna Spreafico, et al.
Published: (2025-01-01)

Le récit et ses limites dans l’œuvre d’Alberto García Alix
by: Anouk Chirol
Published: (2009-05-01)

PRESENCIA DEL MARCADOR LMP-1 DEL VIRUS EPSTEIN-BARR EN LINFOMAS DE CANINOS
by: L. C. Veloza, et al.
Published: (2017-01-01)

The prognostic value of boost dose in residual cervical lymph nodes in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy: a retrospective study
by: Mengting Xu, et al.
Published: (2025-02-01)

Role of rapidly evolving immunotherapy in chronic active Epstein-Barr virus disease
by: Sijia Yan, et al.
Published: (2024-12-01)

Immunotherapy combined with chemotherapy without locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: two case reports and a literature review
by: Yingna Gao, et al.
Published: (2025-01-01)

A self-assembled nanoparticle vaccine elicits effective neutralizing antibody response against EBV infection
by: Ping Li, et al.
Published: (2025-01-01)

PD-L1 mediated immune escape in nasopharyngeal carcinoma: Impact of LMP1 and IFN-γ on immune surveillance
by: Madhan Krishnan, et al.
Published: (2024-12-01)

Corrigendum: A self-assembled nanoparticle vaccine elicits effective neutralizing antibody response against EBV infection
by: Ping Li, et al.
Published: (2025-02-01)

Targeting EBV Episome for Anti-Cancer Therapy: Emerging Strategies and Challenges
by: Febri Gunawan Sugiokto, et al.
Published: (2025-01-01)

EBV-specific T-cell immunity: relevance for multiple sclerosis
by: Malina Behrens, et al.
Published: (2024-12-01)

Interplay of aurora kinase a functional residues and Epstein-barr Nuclear Antigen 1 in Epstein-barr virus associated Gastric cancer using AGS cells
by: Nidhi Varshney, et al.
Published: (2025-01-01)

Genetic variations and clinical significance in young-onset nasopharyngeal cancer: Analysis of EBV interaction with cellular receptor variants and viral glycoproteins
by: Sulistyo Emantoko Dwi Putra, et al.
Published: (2025-01-01)

EBV-associated lymphoadenopathy in a child
by: H.B. Mateiko, et al.
Published: (2024-12-01)

High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study
by: Leyla A. Ovchinnikova, et al.
Published: (2024-11-01)

The probable progression of Epstein-Barr virus (EBV) to chronic active EBV/reactivation weakens the immune response and stimulates Cryptococcus neoformans infection, which invariably proves fatal: a case report and review of the literature
by: Gargee Mishra, et al.
Published: (2025-01-01)

Epstein-Barr virus (EBV) and systemic lupus erythematosus (SLE) association in serological studies
by: Witold Czyż, et al.
Published: (2025-01-01)

DEVELOPMENT OF AN IMPROVED EPSTEIN-BARR VIRUS (EBV) NEUTRALIZING ANTIBODY ASSAY TO FACILITATE DEVELOPMENT OF A PROPHYLACTIC GP350-SUBUNIT EBV VACCINE
by: Hui Liu, et al.
Published: (2020-02-01)

Computational biology assisted exploration of phytochemicals derived natural inhibitors to block BZLF1 gene activation of Epstein–Bar virus in host
by: Muhammad Naveed, et al.
Published: (2024-12-01)

Significant response to pembrolizumab plus lenvatinib in Epstein–Barr-virus-associated intrahepatic cholangiocarcinoma: a case report
by: Lisha Li, et al.
Published: (2024-12-01)

TianTan vaccinia virus-based EBV vaccines targeting both latent and lytic antigens elicits potent immunity against lethal EBV challenge in humanized mice
by: Xinyu Zhang, et al.
Published: (2024-12-01)

Curcumin derivative C210 induces Epstein–Barr virus lytic cycle and inhibits virion production by disrupting Hsp90 function
by: Linli Chen, et al.
Published: (2024-11-01)

The value of a PET scan in selecting the best lymph node to biopsy, and confirming the diagnosis of idiopathic multicentric Castleman disease with HLH and EBV viremia in a previously healthy adult
by: Erica Bitektine, et al.
Published: (2024-11-01)

Fatal Fulminant Epstein–Barr Virus (EBV) Encephalitis in Immunocompetent 5.5-Year-Old Girl—A Case Report with the Review of Diagnostic and Management Dilemmas
by: Magdalena Mierzewska-Schmidt, et al.
Published: (2024-12-01)

Infarct‐like myocarditis with coronary vasculitis and aneurysm formation caused by Epstein–Barr virus infection
by: Cristina Chimenti, et al.
Published: (2020-06-01)

Age-related immunosenescence and Epstein–Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case report
by: Jiayuan Ye, et al.
Published: (2025-01-01)

Detection of Viruses in Dentin Caries and Necrotic Pulp Caries Using ELISA Technique in Mosul, Iraq
by: Enas Yaseen Shehab, et al.
Published: (2024-10-01)

镍、硒对Epstien-Barr病毒抗原表达的效应
Published: (1993-01-01)

Splenic rupture associated with thrombocytopenic purpura caused by infectious mononucleosis. Case report
by: Alicia Santa Cortes González, et al.
Published: (2017-07-01)

Retinal vasculitis associated with Epstein-Barr virus infection in a young immunocompetent patient. First Colombian case report
by: Santiago Sánchez-Pardo, et al.
Published: (2019-07-01)

Prognostic effect of immunohistochemically determined molecular subtypes in gastric cancer
by: Jefim Brodkin, et al.
Published: (2024-12-01)

Lymphomatoid Granulomatosis of Central Nervous System and Lung Driven by Epstein Barr Virus Proliferation: Successful Treatment with Rituximab
by: Ruben Fernandez, et al.
Published: (2014-02-01)

HPRT1: a preliminary investigation on its involvement in nasopharyngeal carcinoma
by: An Chen, et al.
Published: (2024-11-01)

Plasma Epstein-Barr Virus DNA load for diagnostic and prognostic assessment in intestinal Epstein-Barr Virus infection
by: Chunxiang Ma, et al.
Published: (2025-01-01)

KLRB1 expression in nasopharyngeal mucosa as a prognostic biomarker in COVID-19 patients
by: Marilina García-Aranda, et al.
Published: (2025-01-01)

Hematological abnormalities beyond lymphocytosis during infectious mononucleosis: Epstein-Barr virus-induced thrombocytopenia
by: Arturo Gonzalez Quintela, et al.
Published: (2023-02-01)