Solanum lycopersicum exerts cardioprotective effects via reduced creatinine kinase myocardial band and ATPase activities in Wistar rats exposed to lead acetate
Background: Lead exposure is a known risk factor for cardiovascular diseases, yet effective cardioprotective interventions remain inadequately explored. Despite existing research, there is limited clarity on potential natural therapies that can mitigate lead-induced cardiac damage. Objective: This s...
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Elsevier
2025-09-01
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| Series: | Journal of Trace Elements and Minerals |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773050625000448 |
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| author | Olorunsola Israel Adeyomoye Olugbemi Tope Olaniyan Juliana Bunmi Adetunji Oluwaseun Charles Adetunji |
| author_facet | Olorunsola Israel Adeyomoye Olugbemi Tope Olaniyan Juliana Bunmi Adetunji Oluwaseun Charles Adetunji |
| author_sort | Olorunsola Israel Adeyomoye |
| collection | DOAJ |
| description | Background: Lead exposure is a known risk factor for cardiovascular diseases, yet effective cardioprotective interventions remain inadequately explored. Despite existing research, there is limited clarity on potential natural therapies that can mitigate lead-induced cardiac damage. Objective: This study investigates the cardioprotective effects of ethyl acetate extract of Solanum lycopersicum (EESL) in lead-exposed Wistar rats, providing insights into its therapeutic potential and relevance. Methods: Fresh fruits of Solanum lycopersicum (tomatoes) were air-dried, ground, concentrated, and extracted using ethyl acetate. A portion of EESL was analyzed using GC–MS. Fifteen (15) male Wistar rats were randomly assigned to three groups (n = 5 per group): control (distilled water), lead acetate (0.5 mg.mL-1), and lead acetate + EESL (5 mg.kg-1). Lead acetate and EESL were administered via drinking water and oral gavage, respectively, for four weeks. Body weight and lead concentration were measured using a weighing scale and flame atomic absorption spectrometry, respectively. Antioxidants and cardiac biomarkers were assessed using spectrophotometry. Data were analyzed using ANOVA at a significance level of p < 0.05. Results: Gas chromatography mass spectrometry identified 56 constituents, with 6-dehydroprogesterone (-9.3 kcal/mol) showing the highest docking affinity for the beta-adrenergic receptor. There was a significant increase in body weight in the lead acetate + EESL group compared to the lead acetate group. Lead concentration was significantly higher in the lead acetate group compared to the lead acetate + EESL group. SOD activity significantly increased in the lead acetate + EESL group, while CK-MB, Na⁺/K⁺ ATPase, and Ca²⁺ ATPase activities significantly decreased compared to the lead acetate group. Conclusion: Solanum lycopersicum ethyl acetate extract demonstrated cardioprotective effects by enhancing antioxidant activity and reducing cardiac injury markers in lead-exposed rats. However, the associated increase in body weight raises concerns about potential metabolic risks, warranting further investigation |
| format | Article |
| id | doaj-art-4ea7e04afff54f47867a3a8ce9901e9c |
| institution | Kabale University |
| issn | 2773-0506 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Trace Elements and Minerals |
| spelling | doaj-art-4ea7e04afff54f47867a3a8ce9901e9c2025-08-20T03:44:11ZengElsevierJournal of Trace Elements and Minerals2773-05062025-09-011310025310.1016/j.jtemin.2025.100253Solanum lycopersicum exerts cardioprotective effects via reduced creatinine kinase myocardial band and ATPase activities in Wistar rats exposed to lead acetateOlorunsola Israel Adeyomoye0Olugbemi Tope Olaniyan1Juliana Bunmi Adetunji2Oluwaseun Charles Adetunji3Department of Physiology, University of Medical Sciences, Ondo State, Nigeria; Corresponding author.Department of Physiology, Kwara State University, Malete, NigeriaDepartment of Biochemistry, Osun State University, Osogbo, NigeriaDepartment of Microbiology, Edo State University, Uzairue, NigeriaBackground: Lead exposure is a known risk factor for cardiovascular diseases, yet effective cardioprotective interventions remain inadequately explored. Despite existing research, there is limited clarity on potential natural therapies that can mitigate lead-induced cardiac damage. Objective: This study investigates the cardioprotective effects of ethyl acetate extract of Solanum lycopersicum (EESL) in lead-exposed Wistar rats, providing insights into its therapeutic potential and relevance. Methods: Fresh fruits of Solanum lycopersicum (tomatoes) were air-dried, ground, concentrated, and extracted using ethyl acetate. A portion of EESL was analyzed using GC–MS. Fifteen (15) male Wistar rats were randomly assigned to three groups (n = 5 per group): control (distilled water), lead acetate (0.5 mg.mL-1), and lead acetate + EESL (5 mg.kg-1). Lead acetate and EESL were administered via drinking water and oral gavage, respectively, for four weeks. Body weight and lead concentration were measured using a weighing scale and flame atomic absorption spectrometry, respectively. Antioxidants and cardiac biomarkers were assessed using spectrophotometry. Data were analyzed using ANOVA at a significance level of p < 0.05. Results: Gas chromatography mass spectrometry identified 56 constituents, with 6-dehydroprogesterone (-9.3 kcal/mol) showing the highest docking affinity for the beta-adrenergic receptor. There was a significant increase in body weight in the lead acetate + EESL group compared to the lead acetate group. Lead concentration was significantly higher in the lead acetate group compared to the lead acetate + EESL group. SOD activity significantly increased in the lead acetate + EESL group, while CK-MB, Na⁺/K⁺ ATPase, and Ca²⁺ ATPase activities significantly decreased compared to the lead acetate group. Conclusion: Solanum lycopersicum ethyl acetate extract demonstrated cardioprotective effects by enhancing antioxidant activity and reducing cardiac injury markers in lead-exposed rats. However, the associated increase in body weight raises concerns about potential metabolic risks, warranting further investigationhttp://www.sciencedirect.com/science/article/pii/S2773050625000448Solanum lycopersicumLead acetateCardioprotective effectsGC-MSSpectrophotometry |
| spellingShingle | Olorunsola Israel Adeyomoye Olugbemi Tope Olaniyan Juliana Bunmi Adetunji Oluwaseun Charles Adetunji Solanum lycopersicum exerts cardioprotective effects via reduced creatinine kinase myocardial band and ATPase activities in Wistar rats exposed to lead acetate Journal of Trace Elements and Minerals Solanum lycopersicum Lead acetate Cardioprotective effects GC-MS Spectrophotometry |
| title | Solanum lycopersicum exerts cardioprotective effects via reduced creatinine kinase myocardial band and ATPase activities in Wistar rats exposed to lead acetate |
| title_full | Solanum lycopersicum exerts cardioprotective effects via reduced creatinine kinase myocardial band and ATPase activities in Wistar rats exposed to lead acetate |
| title_fullStr | Solanum lycopersicum exerts cardioprotective effects via reduced creatinine kinase myocardial band and ATPase activities in Wistar rats exposed to lead acetate |
| title_full_unstemmed | Solanum lycopersicum exerts cardioprotective effects via reduced creatinine kinase myocardial band and ATPase activities in Wistar rats exposed to lead acetate |
| title_short | Solanum lycopersicum exerts cardioprotective effects via reduced creatinine kinase myocardial band and ATPase activities in Wistar rats exposed to lead acetate |
| title_sort | solanum lycopersicum exerts cardioprotective effects via reduced creatinine kinase myocardial band and atpase activities in wistar rats exposed to lead acetate |
| topic | Solanum lycopersicum Lead acetate Cardioprotective effects GC-MS Spectrophotometry |
| url | http://www.sciencedirect.com/science/article/pii/S2773050625000448 |
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